NMPA Key Laboratory for Quality Research and Control of Tissue Regenerative Biomaterial, Institute of Regulatory Science for Medical Device, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China.
Department of Biotechnology, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Int J Mol Sci. 2022 Sep 10;23(18):10521. doi: 10.3390/ijms231810521.
The over-growth and coagulation of nanoparticles is prevented using capping agents by the production of stearic effect that plays a pivotal role in stabilizing the interface. This strategy of coating the nanoparticles' surface with capping agents is an emerging trend in assembling multipurpose nanoparticles that is beneficial for improving their physicochemical and biological behavior. The enhancement of reactivity and negligible toxicity is the outcome. In this review article, an attempt has been made to introduce the significance of different capping agents in the preparation of nanoparticles. Most importantly, we have highlighted the recent progress, existing roadblocks, and upcoming opportunities of using surface modified nanoparticles in nanomedicine from the drug and gene delivery, bioimaging, and biosensing perspectives.
使用封端剂防止纳米粒子的过度生长和凝聚，通过形成具有稳定界面的关键作用的硬脂酸效应。这种用封端剂涂覆纳米粒子表面的包覆策略是组装多功能纳米粒子的一种新兴趋势，有利于改善它们的物理化学和生物学行为。其结果是提高反应性和可忽略的毒性。在这篇综述文章中，我们试图介绍不同封端剂在纳米粒子制备中的重要性。最重要的是，我们从药物和基因传递、生物成像和生物传感的角度强调了表面修饰纳米粒子在纳米医学中应用的最新进展、存在的障碍和未来的机遇。
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