Royal Adelaide Hospital/Institute of Medical and Veterinary Science, South Australia Health, Government of South Australia, Adelaide, Australia.
Soc Psychiatry Psychiatr Epidemiol. 2011 Dec;46(12):1303-12. doi: 10.1007/s00127-010-0302-3. Epub 2010 Oct 26.
To define specific medical conditions associated with clinically significant depressive symptoms in men.
A cross-sectional study was conducted in a community-based sample of Australian men (N = 1,195, aged 35-80 years; for 2002-2005). Depression was defined by: (1) symptomatic depression (current symptoms) or (2) current prescription for antidepressant(s) or (3) previously diagnosed depression. Logistic regression was used to determine prevalence odds ratios (OR) for depression independently associated with an extensive range of demographic, lifestyle, and clinical factors. Adjusted population attributable risk (PAR%) estimates were also computed.
Depression was significantly (ORs at P < 0.05) associated with previously diagnosed anxiety (12.0) and insomnia (4.4), not married (1.7), current smoker (1.7), low muscle strength tertile (1.7, P = 0.059), high triglycerides (1.6), high storage lower urinary tract symptoms (LUTS) tertile (1.8), past year general practitioner visits 5-9 (1.9), middle energy density tertile (0.4), and high systolic blood pressure (0.5). Significant PAR% estimates (at P < 0.05) were for previous anxiety (27.0%) and insomnia (16.1%), middle energy density tertile (-17.2%), high SBP (-23.5%), high triglycerides (15.2%), and high storage LUTS tertile (12.6%). Results strengthened when depression-related factors (previous anxiety and insomnia, psycholeptics, and cognition) were omitted, and became significant for CVD (OR 1.6; PAR 13.9%).
Medical conditions associated with depression in men include high triglycerides, low muscle strength, CVD, and LUTS. Depressed men are likely to use health services frequently, be current smokers, not be married, eat unhealthily, and report previous diagnosis of anxiety and insomnia; which has important implications for clinicians managing male patients.
确定与男性临床显著抑郁症状相关的特定医学状况。
对澳大利亚社区男性样本（N=1195，年龄 35-80 岁；2002-2005 年）进行横断面研究。抑郁的定义是：（1）症状性抑郁（当前症状）或（2）当前抗抑郁药处方或（3）先前诊断的抑郁。使用逻辑回归确定与广泛的人口统计学、生活方式和临床因素独立相关的抑郁的患病率比值比（OR）。还计算了调整后的人群归因风险（PAR%）估计值。
抑郁与先前诊断的焦虑（12.0）和失眠（4.4）、未婚（1.7）、当前吸烟者（1.7）、肌肉力量低三分位数（1.7，P=0.059）、高甘油三酯（1.6）、高存储下尿路症状（LUTS）三分位数（1.8）、过去一年全科医生就诊 5-9 次（1.9）、中能量密度三分位数（0.4）和高收缩压（0.5）显著相关（P<0.05）。显著的 PAR%估计值（P<0.05）为先前的焦虑（27.0%）和失眠（16.1%）、中能量密度三分位数（-17.2%）、高 SBP（-23.5%）、高甘油三酯（15.2%）和高存储 LUTS 三分位数（12.6%）。当排除与抑郁相关的因素（先前的焦虑和失眠、精神药物和认知）时，结果得到了加强，并且 CVD（OR 1.6；PAR 13.9%）的结果具有统计学意义。
与男性抑郁相关的医学状况包括高甘油三酯、低肌肉力量、CVD 和 LUTS。抑郁的男性可能经常使用卫生服务、当前吸烟、未婚、不健康饮食，并且报告先前诊断出的焦虑和失眠；这对管理男性患者的临床医生具有重要意义。
