Rosivack R G, Koenigsberg S R, Maxwell K C
New Jersey Dental School, Newark.
Anesth Prog. 1990 Nov-Dec;37(6):290-2.
This study compared the effectiveness of topical benzocaine 20%, lidocaine 5%, and a placebo in reducing the pain caused by needle insertion when the medicament was placed in the mucobuccal fold above the maxillary canine eminence. Both topical anesthetics and the placebo were randomly tested against each other bilaterally. For uniformity the agents were left in place for three minutes before needle insertion. A 27 gauge short needle mounted on an aspirating syringe was then inserted just past the bevel. Each subject rated the degree of pain on a visual analogue scale 100 mm in length. A pulse oximeter was used to record the heart rate. The results indicate that both topical anesthetics are significantly better than the placebo in reducing pain caused by needle insertion, although no statistically significant differences were found between the two topical anesthetics. Statistically significant differences in heart rate were seen, but these differences were not clinically significant. It is concluded that benzocaine 20% and lidocaine 5% significantly reduce the pain during needle insertion.
本研究比较了20%的外用苯佐卡因、5%的利多卡因和一种安慰剂在上颌尖牙隆起上方的粘膜颊褶处放置药物时减轻针刺疼痛的效果。两种外用麻醉剂和安慰剂在双侧相互随机测试。为保持一致性，在针刺前将药物放置到位三分钟。然后将安装在抽吸注射器上的27号短针插入刚好超过斜面处。每个受试者在100毫米长的视觉模拟量表上对疼痛程度进行评分。使用脉搏血氧仪记录心率。结果表明，两种外用麻醉剂在减轻针刺疼痛方面均显著优于安慰剂，尽管两种外用麻醉剂之间未发现统计学上的显著差异。观察到心率有统计学上的显著差异，但这些差异在临床上并不显著。得出的结论是，20%的苯佐卡因和5%的利多卡因可显著减轻针刺时的疼痛。
