Dreise Marieke, Galiwango George, Hodges Andrew
Cleft Palate Craniofac J. 2011 Mar;48(2):156-60. doi: 10.1597/09-076. Epub 2010 Apr 23.
The purpose of the study was to estimate the need for resources for cleft repairs in Uganda by determining the overall incidence of oral-facial clefts and the ratio of isolated cleft lip to isolated cleft palate to cleft lip and palate.
A 1-year prospective study was implemented in seven hospitals and health centers with maternity units in and around Kampala. All live babies were examined for cleft lip and/or palate at birth. The birth of a baby with a cleft was communicated to the research coordinator by maternity staff, and the babies were assessed within 24 hours of delivery. Maternity data (live births) for each center were collected monthly to determine the denominator.
Over the course of 1 year (February 1, 2008 to January 31, 2009), 26,186 babies were delivered. Nineteen babies had a cleft lip and/or palate, giving an incidence of 0.73 in 1000; 12 of the 19 babies (63.2%) had a cleft lip and palate, six (31.2%) had an isolated cleft lip, and only one (5.3%) had an isolated cleft palate. The ratio of boys to girls was 1.1∶1.
The incidence of clefts in this study was 0.73 in 1000. With an estimated 1100 babies born with a cleft per year, this would result in the need for 1800 cleft repairs for babies in Uganda (695 babies needing two repairs each). These data will be helpful to advocate for and plan the necessary resources to effectively treat this condition.
本研究旨在通过确定口腔面部裂的总体发病率以及单纯唇裂、单纯腭裂与唇腭裂的比例，来估计乌干达唇腭裂修复所需的资源。
在坎帕拉及其周边地区设有产科病房的七家医院和健康中心开展了一项为期1年的前瞻性研究。所有活产婴儿在出生时均接受唇裂和/或腭裂检查。产科工作人员将唇腭裂婴儿的出生情况告知研究协调员，并在分娩后24小时内对婴儿进行评估。每月收集每个中心的产科数据（活产数）以确定分母。
在1年期间（2008年2月1日至2009年1月31日），共分娩26186名婴儿。19名婴儿患有唇裂和/或腭裂，发病率为千分之0.73；19名婴儿中有12名（63.2%）患有唇腭裂，6名（31.2%）患有单纯唇裂，只有1名（5.3%）患有单纯腭裂。男女性别比为1.1∶1。
本研究中唇腭裂的发病率为千分之0.73。据估计，乌干达每年有1100名唇腭裂婴儿出生，这将导致需要为1800名婴儿进行唇腭裂修复（695名婴儿需要进行两次修复）。这些数据将有助于倡导并规划有效治疗这种疾病所需的资源。
