Laboratorio di Chimica-Clinica, Ematologia e Microbiologia, Azienda Ospedaliera, S Antonio Abate, Gallarate, Varese, Italy.
Int J Lab Hematol. 2011 Apr;33(2):219-25. doi: 10.1111/j.1751-553X.2010.01271.x. Epub 2010 Oct 27.
The study was designed to evaluate whether there was a statistically significant effect between evacuated glass tubes and plastic tubes on prothrombin time (PT) and activated partial thromboplastin time (aPTT).
Blood samples were drawn into four different tubes from three patient populations-apparently healthy patients, patients on oral anticoagulant therapy with vitamin K antagonists (OAT-vka) and patients being treated with unfractioned heparin (UFH). Testing was performed on an automated coagulation analyzer, and statistical analysis was achieved using a test of variance (anova).
For normal patients, there were no statistically significant differences for the aPTT test; however, there were statistically significant differences for the PT test. For patients on OAT-vka, statistically significant differences were clearly observed between the four tube types for the PT test. For patients treated with UFH, there were no statistically significant differences for the aPTT test.
The data showed a statistically significant difference between glass and plastic tubes in the normal population only for the PT test, with consequent repercussions for patients on OAT. This means that appropriate care and validation should take place whenever there is a change in tube type.
本研究旨在评估在凝血酶原时间（PT）和活化部分凝血活酶时间（aPTT）方面，抽空玻璃管和塑料管之间是否存在统计学显著差异。
从三个患者群体（健康患者、接受维生素 K 拮抗剂（OAT-vka）口服抗凝治疗的患者和接受未分级肝素（UFH）治疗的患者）中抽取了四种不同的管内血液样本。在自动化凝血分析仪上进行检测，并使用方差检验（anova）进行统计分析。
对于正常患者，aPTT 测试没有统计学显著差异；然而，PT 测试存在统计学显著差异。对于接受 OAT-vka 的患者，PT 测试中四种管型之间存在明显的统计学差异。对于接受 UFH 治疗的患者，aPTT 测试无统计学显著差异。
数据显示，在正常人群中，玻璃管和塑料管之间仅在 PT 测试方面存在统计学显著差异，这对接受 OAT 的患者产生了相应的影响。这意味着，当管型发生变化时，应进行适当的护理和验证。
