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过优越的生活：高原适应。

Living the high life: high-altitude adaptation.

机构信息

Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA.

出版信息

Genome Biol. 2010;11(9):133. doi: 10.1186/gb-2010-11-9-133. Epub 2010 Sep 10.

DOI:10.1186/gb-2010-11-9-133
PMID:20979669
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2965377/
Abstract

Genome-wide scans demonstrate that genetic variants associated with high-altitude adaptation in Tibetans and Andeans arose independently as a result of convergent adaptation.

摘要

全基因组扫描表明，与藏族人和安第斯人高原适应相关的遗传变异是由于趋同适应而独立出现的。

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本文引用的文献

1
Andean, Tibetan, and Ethiopian patterns of adaptation to high-altitude hypoxia.安第斯、藏人和埃塞俄比亚人适应高原缺氧的模式。
Integr Comp Biol. 2006 Feb;46(1):18-24. doi: 10.1093/icb/icj004. Epub 2006 Jan 6.
2
Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data.利用密集基因组扫描数据鉴定藏人和安第斯人自然选择的特征。
PLoS Genet. 2010 Sep 9;6(9):e1001116. doi: 10.1371/journal.pgen.1001116.
3
Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders.自然选择对 EPAS1（HIF2alpha）的影响导致藏高原人群中血红蛋白浓度降低。
Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11459-64. doi: 10.1073/pnas.1002443107. Epub 2010 Jun 7.
4
Genetic evidence for high-altitude adaptation in Tibet.遗传证据表明西藏存在高原适应现象。
Science. 2010 Jul 2;329(5987):72-5. doi: 10.1126/science.1189406. Epub 2010 May 13.
5
Identifying positive selection candidate loci for high-altitude adaptation in Andean populations.鉴定安第斯人群适应高海拔的正选择候选基因座。
Hum Genomics. 2009 Dec;4(2):79-90. doi: 10.1186/1479-7364-4-2-79.
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Constructing genomic maps of positive selection in humans: where do we go from here?构建人类正向选择的基因组图谱：我们从这里走向何方？
Genome Res. 2009 May;19(5):711-22. doi: 10.1101/gr.086652.108.
7
Higher offspring survival among Tibetan women with high oxygen saturation genotypes residing at 4,000 m.居住在4000米高度、具有高血氧饱和度基因型的藏族女性的后代存活率更高。
Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14300-4. doi: 10.1073/pnas.0405949101. Epub 2004 Sep 7.
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Maternal adaptation to high-altitude pregnancy: an experiment of nature--a review.母亲对高原妊娠的适应：一项自然实验——综述
Placenta. 2004 Apr;25 Suppl A:S60-71. doi: 10.1016/j.placenta.2004.01.008.
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Gene ontology: tool for the unification of biology. The Gene Ontology Consortium.基因本体论：生物学统一工具。基因本体论联合会。
Nat Genet. 2000 May;25(1):25-9. doi: 10.1038/75556.
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The hypoxic response: huffing and HIFing.缺氧反应：喘息与低氧诱导因子作用
Cell. 1997 Apr 4;89(1):9-12. doi: 10.1016/s0092-8674(00)80176-2.