Yu Xue-ying, Wang Gui-hong, Guan Xiao-ting, Liu Yun, Wang Su-xiang, Liu Zhi-zhong, Wang Yong-jun
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
Zhonghua Nei Ke Za Zhi. 2010 Jun;49(6):488-90.
To investigate the aging features of pure leukoaraiosis (LA) in non-demented outpatients.
The outpatients with age older than 40 years, without taking cholesterol lowering and B vitamin medications and with mini-mental state examination more than 24 scores were selected from July 2008 to December. 2009 in Beijing Tiantan Hospital. LA was defined with MRI. Patients were classified into two groups i.e. LA group consisting of 138 patients with leukoaraiosis but without lacunar lesions and cortical infarcts and a control group consisting of 124 patients without any lesion in brain. Age and other vascular risk factors were also investigated.
Age of the patients in the LA group was significantly higher than that in the control group (P<0.001). Multivariable logistic regression analysis showed that age was independently associated with pure LA (OR 1.080, 95%CI 1.042-1.120), after adjusting sex, vascular risk factors and presence of atherosclerosis in cervical arteries. If age-stratification was further considered, logistic regression analysis showed that OR (95%CI) for LA was 2.693 (95%CI 1.103-6.575) in a 60-69 year group and 13.527 (95%CI 3.319-55.131) in a ≥70 year group as compared with a 40-49 year group.
Age is a determining risk factor for pure LA and patients with age older than 60 years are at high risk of LA.
探讨非痴呆门诊患者单纯脑白质疏松（LA）的老化特征。
选取2008年7月至2009年12月在北京天坛医院就诊的年龄大于40岁、未服用降胆固醇及B族维生素药物且简易精神状态检查得分大于24分的门诊患者。通过MRI定义LA。患者分为两组，即LA组，包括138例有脑白质疏松但无腔隙性病变和皮质梗死的患者；对照组，包括124例脑内无任何病变的患者。同时调查年龄及其他血管危险因素。
LA组患者年龄显著高于对照组（P<0.001）。多变量逻辑回归分析显示，在调整性别、血管危险因素及颈动脉硬化情况后，年龄与单纯LA独立相关（OR 1.080，95%CI 1.042 - 1.120）。若进一步考虑年龄分层，逻辑回归分析显示，与40 - 49岁组相比，60 - 69岁组LA的OR（95%CI）为2.693（95%CI 1.103 - 6.575），≥70岁组为13.527（95%CI 3.319 - 55.131）。
年龄是单纯LA的决定性危险因素，60岁以上患者患LA的风险较高。
