Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Fertil Steril. 2013 Aug;100(2):500-4. doi: 10.1016/j.fertnstert.2013.03.047. Epub 2013 Apr 25.
To investigate the relationship between leukoaraiosis (LA) and menopause in healthy middle-aged women.
A retrospective cohort study.
Health promotion center of a university hospital.
PATIENT(S): We studied 262 healthy pre- and postmenopausal women ages 41-60 years who visited the health promotion center for a routine health checkup.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): LA is defined as diffuse white matter abnormalities on computed tomography or magnetic resonance imaging (MRI). LA was assessed by examining MRIs and using the rating scale of the Atherosclerosis Risk in Communities Study. Logistic regression analysis was performed to examine associations between LA and menopause.
RESULT(S): Women with LA had a significantly higher age than women without LA. Elevated blood pressure (≥ 130/85 mm Hg) and low high-density lipoprotein cholesterol (<50 mg/dL) were frequent abnormal findings in women with LA. The proportion of menopause was significantly higher in women with LA than in those without LA. Menopause was independently associated with the presence of LA (adjusted odds ratio, 2.24; 95% confidence interval, 1.10, 4.60) after adjusting for confounding variables.
CONCLUSION(S): Menopause was significantly associated with LA. Loss of estrogen may play an important role in the development of LA.
探讨中年健康女性脑白质疏松症（LA）与绝经的关系。
回顾性队列研究。
某大学医院健康促进中心。
我们研究了 262 名年龄在 41-60 岁的健康绝经前和绝经后女性，她们因常规健康检查而到健康促进中心就诊。
无。
LA 定义为计算机断层扫描或磁共振成像（MRI）上弥漫性白质异常。通过检查 MRI 和使用社区动脉粥样硬化风险研究的评分量表来评估 LA。采用 logistic 回归分析来检查 LA 与绝经之间的关系。
患有 LA 的女性年龄明显高于无 LA 的女性。高血压（≥130/85mmHg）和低高密度脂蛋白胆固醇（<50mg/dL）是 LA 女性常见的异常发现。患有 LA 的女性中绝经的比例明显高于无 LA 的女性。在校正混杂变量后，绝经与 LA 的存在具有显著相关性（调整后的优势比，2.24；95%置信区间，1.10，4.60）。
绝经与 LA 显著相关。雌激素的丧失可能在 LA 的发展中起重要作用。
