People's Hospital of Zhengzhou, Zhengzhou, Henan Province, China.
Asia Pac J Public Health. 2013 Jul;25(4 Suppl):64S-71S. doi: 10.1177/1010539513493111.
Leukoaraiosis (LA) describes abnormal changes in the cerebral white matter frequently seen on CT and MRI in older adults. Its appearance indicates mild brain injury, and it is often regarded as a mark of senile dementia. Through the analysis of related risk factors of 6000 patients with LA diagnosed by cranial MRI in our department, we found that age, cerebral infarction, lacunar infarction, history of brain hemorrhage, and increased triglycerides were risk factors for LA, and the relative risk odds ratio values were 2.135 (95% confidence interval [CI] = 1.874-2.501), 3.330 (95% CI = 1.922-3.997), 3.412 (95% CI = 2.986-3.512), 3.611 (95% CI = 2.054-9.147), and 1.457 (95% CI = 1.058-1.769), respectively. Through the identification of the risk factors for LA and effective interventions, the occurrence of dementia, stroke, and premature death may be effectively prevented.
脑白质疏松症（LA）描述了老年人 CT 和 MRI 上常见的脑白质异常改变。其表现提示轻度脑损伤，常被视为老年痴呆的标志。通过对我科经头颅 MRI 诊断为 LA 的 6000 例患者的相关危险因素进行分析，发现年龄、脑梗死、腔隙性脑梗死、脑出血史和甘油三酯升高是 LA 的危险因素，相对危险比的比值分别为 2.135（95%可信区间 [CI] = 1.874-2.501）、3.330（95% CI = 1.922-3.997）、3.412（95% CI = 2.986-3.512）、3.611（95% CI = 2.054-9.147）和 1.457（95% CI = 1.058-1.769）。通过识别 LA 的危险因素并进行有效干预，可能有效预防痴呆、中风和过早死亡的发生。
