Wu Jun-ping, Song Zhen-ya, Xu Yi, Zhang Yi-min, Shen Rong-hai
Department of Gastroenterology, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.
Zhonghua Nei Ke Za Zhi. 2010 Jul;49(7):587-90.
To investigate the sleep features in the patients with irritable bowel syndrome (IBS) and compare the sleep quality between those IBS patients who were with and without anxiety and depression.
Pittsburgh sleep quality index questionnaire (PSQI), self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were measured in the 145 IBS patients and 59 regular physical examination volunteers. IBS patients were also divided into two subgroups--patients with or without anxiety and depression based on cutoff scores of SAS and SDS. Comparisons of sleep quality were made between subgroups, and between IBS patients and volunteer controls.
Compared with the controls, the SAS raw score, SDS raw score and SAS positive incidence in IBS patients were shown statistically significant differences (P<0.05), while the SDS positive incidence had no statistically significant difference (P>0.05). PSQI total scores were significantly higher in the IBS patients without anxiety and depression (P<0.05), 3 domains (sleep quality, sleep disturbances and daytime function disorder) were also found statistically significant differences (P<0.05), compared with the controls. The IBS patients with anxiety and depression were statistically significantly different from the controls (P<0.05) in 6 domains (sleep quality, sleep latency, sleep efficiency, sleep disturbances, sleep time and daytime function disorder) and significantly higher PSQI total scores (P<0.05). Statistically significant differences (P<0.05) were also found in all 7 domains and with higher PSQI total scores in IBS patients with anxiety and depression, compared with IBS patients without anxiety and depression.
IBS patients were more likely to have sleep abnormality, mainly in sleep quality, sleep disturbances and daytime function disorder and PSQI total scores. The abnormalities of these factors were independent of emotional disorder. However, emotional disorder worsened the sleep disorder in IBS patients.
探讨肠易激综合征（IBS）患者的睡眠特征，并比较伴有和不伴有焦虑抑郁的IBS患者的睡眠质量。
对145例IBS患者和59名常规体检志愿者进行匹兹堡睡眠质量指数问卷（PSQI）、自评焦虑量表（SAS）和自评抑郁量表（SDS）测评。IBS患者还根据SAS和SDS的临界值分为两个亚组——伴有或不伴有焦虑抑郁的患者。比较亚组之间、IBS患者与志愿者对照组之间的睡眠质量。
与对照组相比，IBS患者的SAS原始得分、SDS原始得分及SAS阳性发生率差异有统计学意义（P<0.05），而SDS阳性发生率差异无统计学意义（P>0.05）。与对照组相比，无焦虑抑郁的IBS患者PSQI总分显著更高（P<0.05），在3个领域（睡眠质量、睡眠障碍和日间功能障碍）也发现差异有统计学意义（P<0.05）。伴有焦虑抑郁的IBS患者在6个领域（睡眠质量、入睡时间、睡眠效率、睡眠障碍、睡眠时间和日间功能障碍）与对照组差异有统计学意义（P<0.05），PSQI总分显著更高（P<0.05）。与无焦虑抑郁的IBS患者相比，伴有焦虑抑郁的IBS患者在所有7个领域差异均有统计学意义（P<0.05），且PSQI总分更高。
IBS患者更易出现睡眠异常，主要表现为睡眠质量、睡眠障碍和日间功能障碍及PSQI总分。这些因素的异常与情绪障碍无关。然而，情绪障碍会加重IBS患者的睡眠障碍。
