Konopacka M, Grzybowska E, Michalska J
Department of Tumor Biology, Institute of Oncology, Gliwice, Poland.
Pol J Pharmacol Pharm. 1990 Sep-Oct;42(5):471-7.
Metronidazole [1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole] and P1 derivative [1-(2-hydroxy-3-methoxypropyl)-2-methyl-4-nitroimidazole] were investigated for their genotoxic activity in two eukaryotic tests: mitotic recombination in yeast and micronucleus test in mice. Both compounds showed no genotoxicity in these eukaryotic assays contrary to their well-documented mutagenic activity in microbial short-term tests.
甲硝唑[1-(2-羟乙基)-2-甲基-5-硝基咪唑]和P1衍生物[1-(2-羟基-3-甲氧基丙基)-2-甲基-4-硝基咪唑]在两项真核生物试验中被研究其遗传毒性活性：酵母中的有丝分裂重组和小鼠中的微核试验。与它们在微生物短期试验中充分记录的诱变活性相反，这两种化合物在这些真核生物试验中均未显示出遗传毒性。
