Golda V, Petr R
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1990;33(2):177-89.
The observations were carried out in the adult normotensive rats of Wistar strain and in the genetically hypertensive rats developed by Koletsky, i.e., in the strain where is decreased turnover-rate of diencephalo-mesecephalic norepinephrine, increased CNS cholinergic activity accompanied by cholinergic supersensitivity and reduced stress-resistance. The effect of dihydroergotoxine was traced in holeboard and in the elevated plus-maze. Chronic dihydroergotoxine treatment shows "anxiolytic" effect in the elevated plus-maze (i.e., this drug alleviates aversion towards open space and height), increases directed exploration, elevates the rate of habituation of the locomotor-exploratory activity at all, and elevates the rate of habituation of directed exploration especially. The drug in the above mentioned parameters shows very expressive dependent effect, i.e., the effect being more or solely expressed in the genetically hypertensive rats of Koletsky type. The results of our recent series of experiments again suggest that is is well founded to use for the screening of the drugs with potential anxiolytic effect the genetically hypertensive rats of Koletsky type, i.e., the strain which by its CNS neurotransmitter abnormalities resembles deviations observed in the patients suffering from anxio-depressive disorders.
这些观察是在Wistar品系的成年正常血压大鼠以及由科列茨基培育的遗传性高血压大鼠中进行的，即在间脑-中脑去甲肾上腺素周转率降低、中枢神经系统胆碱能活性增加并伴有胆碱能超敏反应且应激抵抗力降低的品系中进行的。在洞板试验和高架十字迷宫试验中追踪了双氢麦角毒碱的作用。长期给予双氢麦角毒碱治疗在高架十字迷宫试验中显示出“抗焦虑”作用（即该药物减轻对开放空间和高处的厌恶），增加定向探索，总体上提高运动探索活动的习惯化速率，尤其提高定向探索的习惯化速率。在上述参数方面，该药物显示出非常明显的依赖效应，即该效应在科列茨基型遗传性高血压大鼠中表现得更为明显或仅在该品系大鼠中表现出来。我们最近一系列实验的结果再次表明，利用科列茨基型遗传性高血压大鼠来筛选具有潜在抗焦虑作用的药物是有充分依据的，即该品系大鼠由于其中枢神经系统神经递质异常，类似于在患有焦虑抑郁障碍的患者中观察到的偏差。
