Golda V, Petr R
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1989;32(4):407-23.
The experiments were performed in the older adult (10-14 months of age) normotensive rats of Wistar strain and in the genetically hypertensive rats which developed Koletsky; the experiments were performed in both sexes. The behavior of control and diazepam treated rats were traced in the holeboard and in the elevated plus-maze. In the control animals when compared to the normotensive rats of both sexes show increase in total time of locomotor-exploratory activity in holeboard. In control animals the lowest level of directed exploration was found in the genetically hypertensive males. The control genetically hypertensive males show also the highest aversion towards open space and hight in the elevated plus-maze. Diazepam increases directed exploration in the genetically hypertensive rats of both sexes; directed exploration in the normotensive rats is not influenced by diazepam or this drug caused decrease. Diazepam shows no effect in between-session habituation of directed exploration in the normotensive rats of both sexes; in the genetically hypertensive rats under diazepam treatment instead of between-session habituation of directed exploration there appears in the second session elevation of directed exploration. Diazepam treatment alleviates in the first session aversion towards open space and hight in the elevated plus-maze only in the genetically hypertensive rats of both sexes and in the normotensive males. In the second session statistically significant alleviation of aversion towards open space and hight was attained in both strains of rats, in both sexes and under the both doses of diazepam. Considering the different markers of aging, stress plasma corticosterone and/or diazepam induced hypothermia show tighter age dependence in the genetically hypertensive rats than in the normotensive rats of Wistar strain. On the other hand, the effect of diazepam on aversion towards open space and hight show closer age dependence in the latter type of rats.
实验在10 - 14月龄的Wistar品系老年正常血压大鼠以及遗传性高血压的Koletsky大鼠中进行；雌雄两性大鼠均参与实验。在洞板实验和高架十字迷宫实验中追踪对照大鼠和地西泮处理大鼠的行为。与两性正常血压大鼠相比，对照动物在洞板实验中的运动探索活动总时间增加。在对照动物中，遗传性高血压雄性大鼠的定向探索水平最低。对照遗传性高血压雄性大鼠在高架十字迷宫中对开放空间和高处也表现出最高的厌恶。地西泮增加了两性遗传性高血压大鼠的定向探索；正常血压大鼠的定向探索不受地西泮影响或该药物导致其降低。地西泮对两性正常血压大鼠定向探索的实验间习惯化无影响；在接受地西泮治疗的遗传性高血压大鼠中，第二次实验中定向探索没有出现实验间习惯化，反而升高。地西泮治疗仅在两性遗传性高血压大鼠和正常血压雄性大鼠的第一次实验中减轻了在高架十字迷宫中对开放空间和高处的厌恶。在第二次实验中，两种品系的大鼠、两性以及两种剂量的地西泮均使对开放空间和高处的厌恶得到统计学上显著的减轻。考虑到衰老的不同标志物，应激血浆皮质酮和/或地西泮诱导的体温过低在遗传性高血压大鼠中比在Wistar品系正常血压大鼠中表现出更紧密的年龄依赖性。另一方面，地西泮对开放空间和高处厌恶的影响在后者类型的大鼠中表现出更紧密的年龄依赖性。
