Golda V, Petr R
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1989;32(1):135-47.
The experiments were carried out in the younger adult (3 to 5 months of age) normotensive rats of Wistar strain and in the genetically hypertensive rats which were developed by Koletsky; the experiments were performed in both sexes. The behaviour of control and diazepam treated rats were traced in the holeboard and in the elevated plus-maze. In the control animals when compared to the normotensive rats of both sexes, the genetically hypertensive rats of both sexes show elevated aversion towards open space and hight (when the number of visits of centre and open arms is considered), and elevated total time of locomotor-exploratory activity; the hypertensive males show decrease and female increase in time spent and in number of head-dipping. Diazepam at both doses (0.5-1.0 mg/kg b. w.) alleviates aversion towards open space and hight in the elevated plus-maze only in the genetically hypertensive rats. Directed exploration (head-dipping) was increased in the genetically hypertensive rats of both sexes at both doses of diazepam; at higher dose directed exploration was decreased in the normotensive males. Diazepam shows no effect in the between-session habituation of directed exploration in the normotensive rats of both sexes; in the genetically hypertensive rats instead of the between-session habituation of directed exploration, in the second session (relative to the first one) there appeared elevation of directed exploration.
实验在年轻成年（3至5月龄）的Wistar品系正常血压大鼠以及由科列茨基培育的遗传性高血压大鼠中进行；实验在雌雄两性大鼠中开展。在洞板实验和高架十字迷宫实验中追踪对照大鼠和地西泮处理大鼠的行为。与两性正常血压大鼠相比，对照动物中两性遗传性高血压大鼠对开放空间和高处表现出更高的厌恶（以进入中央区域和开放臂的次数计），且运动探索活动的总时长增加；高血压雄性大鼠头部探入的时间和次数减少，而雌性大鼠则增加。两种剂量（0.5 - 1.0毫克/千克体重）的地西泮仅在遗传性高血压大鼠中减轻了在高架十字迷宫中对开放空间和高处的厌恶。两种剂量的地西泮均增加了两性遗传性高血压大鼠的定向探索（头部探入）；较高剂量时，正常血压雄性大鼠的定向探索减少。地西泮对两性正常血压大鼠定向探索的实验间习惯化没有影响；在遗传性高血压大鼠中，定向探索没有出现实验间习惯化，而是在第二个实验时段（相对于第一个时段）出现了定向探索增加。
