Golda V, Petr R
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1989;32(1):95-108.
The experiments were carried out in the adult normotensive rats of Wistar strain and in the genetically hypertensive rats of Koletsky type; both sexes were used. The behavior in control and in druged animals was traced in new environment, in holeboard and in elevated plus-maze. In the control animals, when compared to the normotensive rats of Wistar strain, the genetically hypertensive rats of both sexes show elevated neophobia, reduced rate habituation of exploratory activity; the males of the latter strain then show reduced rate of rearing in holeboard and elevated aversion towards open space and hight in the elevated plus-maze. Metergoline at the dose 8 mg/kg b.w. normalized the rate of habituation of exploratory activity, reduced the aversion towards the open space and hight in elevated plus-maze in the genetically hypertensive rats of both sexes in the first session, in the males of normotensive rats in the second session. Moreover, Metergoline elevated directed exploration in the normotensive males and in both sexes of the genetically hypertensive rats and elevated rearing in the males of the genetically hypertensive rats. It can be concluded that Metergoline represents a potential anxiolytic drug.
实验在成年Wistar品系正常血压大鼠和科列茨基型遗传性高血压大鼠中进行，雌雄两性均使用。在新环境、洞板和高架十字迷宫中追踪对照动物和用药动物的行为。与Wistar品系正常血压大鼠相比，在对照动物中，两种性别的遗传性高血压大鼠均表现出更高的新异恐惧，探索活动的习惯化速率降低；后一品系的雄性大鼠在洞板中的竖立体位频率降低，在高架十字迷宫中对开放空间和高处的厌恶增加。剂量为8mg/kg体重的麦角新碱在第一阶段使两种性别的遗传性高血压大鼠探索活动的习惯化速率正常化，降低了在高架十字迷宫中对开放空间和高处的厌恶，在第二阶段使正常血压雄性大鼠的上述指标正常化。此外，麦角新碱提高了正常血压雄性大鼠以及遗传性高血压大鼠两性的定向探索能力，并提高了遗传性高血压雄性大鼠的竖立体位频率。可以得出结论，麦角新碱是一种潜在的抗焦虑药物。
