Tornóczky T, Csanaky G, Fischer J
Department of Pathology, University Medical School, Pécs, Hungary.
Acta Morphol Hung. 1990;38(2):85-93.
The authors performed a comparative lectin histochemical study on lymphoid organs of three species with 12 different lectins. The T and B cell regions and the accessory cells of lymphoid tissues were studied. The species differences show that the BALB/c mouse can be a valuable tool in modelling human lymphoid tissues, whereas Wistar rats exhibit great differences in lectin binding patterns as compared with human tissues. The positivity of peanut agglutinin binding of cortical and the negativity of medullar thymocytes in mice can be regarded as an indicator of cell differentiation. The focal distribution of peanut agglutinin positivity in the centrocytic region of human and rat germinal centres marks a small B cell subpopulation at the early stage of differentiation, while Bandeira simplicifolia binding is characteristic of a broader B cell lineage, but only in rats and mice. Canavalia ensiformis lectin seems to be a reliable marker of accessory cells (dendritic and interdigitating reticulum cells as well as macrophages) in all species studied.
作者用12种不同的凝集素对三个物种的淋巴器官进行了比较凝集素组织化学研究。对淋巴组织的T和B细胞区域以及辅助细胞进行了研究。物种差异表明，BALB/c小鼠可作为模拟人类淋巴组织的有价值工具，而与人类组织相比，Wistar大鼠在凝集素结合模式上表现出很大差异。小鼠皮质花生凝集素结合的阳性和髓质胸腺细胞的阴性可被视为细胞分化的指标。花生凝集素阳性在人和大鼠生发中心中心细胞区域的局灶性分布标志着分化早期的一个小B细胞亚群，而简单叶刀豆凝集素的结合是更广泛B细胞谱系的特征，但仅在大鼠和小鼠中。刀豆凝集素似乎是所有研究物种中辅助细胞（树突状和交错网状细胞以及巨噬细胞）的可靠标志物。
