花生凝集素结合位点作为正常和恶性人类淋巴细胞分化标志物的分析
Analysis of the peanut agglutinin-binding site as a differentiation marker of normal and malignant human lymphoid cells.
作者信息
Galili U, Galili N, Or R, Polliack A
出版信息
Clin Exp Immunol. 1981 Feb;43(2):311-8.
The lectin peanut agglutinin (PNA), which interacts specifically with D-galactosyl residues, was studied for its binding to human normal and malignant lymphoid cells at various stages of differentiation. As previously reported, PNA binds to thymocytes; however, it does not interact with the prothymocytes which precede the cortical thymocyte differentiation stage. No mature peripheral cells in any of the lymphoid organs bind PNA. In contrast to the normal T differentiation pathway, the expression of the PNA-binding site does not seem to coincide with that of T cell characteristics in the various malignant lymphoid cells studied. We therefore conclude that more information is needed about the nature of the PNA-binding site before it can be used as a differentiation marker in malignant lymphoid cells.
凝集素花生凝集素（PNA）能与D - 半乳糖基残基特异性相互作用，本研究探讨了其在不同分化阶段与人类正常及恶性淋巴样细胞的结合情况。如先前报道，PNA可与胸腺细胞结合；然而，它不与皮质胸腺细胞分化阶段之前的原胸腺细胞相互作用。任何淋巴器官中的成熟外周细胞均不结合PNA。与正常T细胞分化途径不同，在所研究的各种恶性淋巴样细胞中，PNA结合位点的表达似乎与T细胞特征的表达不一致。因此，我们得出结论，在将PNA结合位点用作恶性淋巴样细胞的分化标志物之前，需要更多关于其性质的信息。
Zotero 插件