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花生凝集素与胸腺皮质及淋巴组织生发中心的结合。

Binding of peanut lectin to thymic cortex and germinal centres of lymphoid tissue.

作者信息

Rose M L, Malchiodi F

出版信息

Immunology. 1981 Apr;42(4):583-91.

PMID:6972347
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1458258/
Abstract

The binding pattern of horseradish peroxidase conjugated peanut lectin (HRP-PNL) on frozen sections of lymphoid tissue from man, mouse, rat, hamster, guinea-pig, rabbit, sheep and chicken has been investigated. Binding of PNL was found to be highly species dependent; man, mouse and sheep showed strong binding to lymphocytes in thymic cortex and germinal centres; lymphoid tissue from hamster, guinea-pig and rabbit did not stain with HRP-PNL and rat showed only lightly positive cells in thymic cortex and germinal centres; all lymphoid tissue from chicken, except the bursal cortex, bound PNL. Neuraminidase treatment of tissues which did not bind PNL resulted in strongly PNL-positive cells. Double binding studies on murine Peyer's patches with fluorescein isothiocyanate conjugated PNL (FITC-PNL) and tetramethylrhodamine isothiocyanate (TRITC)-anti-Thy-1.2 or anti-immunoglobulin reagents revealed 3%-10% of PNL positive cells to be Thy-1.2 positive and 70%-80% to bear surface immunoglobulin.

摘要

已对辣根过氧化物酶偶联花生凝集素（HRP-PNL）在人、小鼠、大鼠、仓鼠、豚鼠、兔、绵羊和鸡的淋巴组织冰冻切片上的结合模式进行了研究。发现PNL的结合具有高度的物种依赖性；人、小鼠和绵羊的胸腺皮质和生发中心的淋巴细胞显示出强烈结合；仓鼠、豚鼠和兔的淋巴组织未被HRP-PNL染色，大鼠仅在胸腺皮质和生发中心显示弱阳性细胞；鸡的所有淋巴组织，除了法氏囊皮质外，均结合PNL。对未结合PNL的组织进行神经氨酸酶处理后，产生了强PNL阳性细胞。用异硫氰酸荧光素偶联PNL（FITC-PNL）和异硫氰酸四甲基罗丹明（TRITC）-抗Thy-1.2或抗免疫球蛋白试剂对小鼠派伊尔结进行的双重结合研究显示，3%-10%的PNL阳性细胞为Thy-1.2阳性，70%-80%的细胞带有表面免疫球蛋白。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fc/1458258/2f25f9e0e7c8/immunology00245-0090-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fc/1458258/c6b50cc5e35a/immunology00245-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fc/1458258/d73f73158dbf/immunology00245-0089-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fc/1458258/8bffa206d24d/immunology00245-0089-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fc/1458258/0e0355e299e8/immunology00245-0090-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fc/1458258/2f25f9e0e7c8/immunology00245-0090-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fc/1458258/c6b50cc5e35a/immunology00245-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fc/1458258/d73f73158dbf/immunology00245-0089-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fc/1458258/8bffa206d24d/immunology00245-0089-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fc/1458258/0e0355e299e8/immunology00245-0090-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fc/1458258/2f25f9e0e7c8/immunology00245-0090-b.jpg

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本文引用的文献

1
Peanut lectin binding properties of germinal centres of mouse lymphoid tissue.小鼠淋巴组织生发中心的花生凝集素结合特性
Nature. 1980 Mar 27;284(5754):364-6. doi: 10.1038/284364a0.
2
Expression of binding sites for peanut agglutinin during murine B lymphocyte differentiation.花生凝集素结合位点在小鼠B淋巴细胞分化过程中的表达
Immunology. 1980 Jun;40(2):193-200.
3
The interaction of Ricinus communis agglutinin with normal and tumor cell surfaces.蓖麻凝集素与正常细胞及肿瘤细胞表面的相互作用。
自身反应性 T 和 B 细胞诱导肺部支气管相关淋巴组织的发育。
Am J Respir Cell Mol Biol. 2013 Apr;48(4):406-14. doi: 10.1165/rcmb.2012-0065OC.
4
PNA-binding glycans are expressed at high levels on horse mature and immature T lymphocytes and a subpopulation of B lymphocytes.肽核酸结合聚糖在马的成熟和未成熟T淋巴细胞以及B淋巴细胞亚群上高水平表达。
Glycoconj J. 2005 Feb;22(1-2):27-34. doi: 10.1007/s10719-005-0228-2.
5
Generation of mice deficient for macrophage galactose- and N-acetylgalactosamine-specific lectin: limited role in lymphoid and erythroid homeostasis and evidence for multiple lectins.巨噬细胞半乳糖和N - 乙酰半乳糖胺特异性凝集素缺陷小鼠的产生：在淋巴细胞和红细胞稳态中的作用有限及多种凝集素的证据
Mol Cell Biol. 2002 Jul;22(14):5173-81. doi: 10.1128/MCB.22.14.5173-5181.2002.
6
JL1, a novel differentiation antigen of human cortical thymocyte.JL1，一种人类皮质胸腺细胞的新型分化抗原。
J Exp Med. 1993 Oct 1;178(4):1447-51. doi: 10.1084/jem.178.4.1447.
7
Lymphocyte cell surface glycoproteins which bind to soybean and peanut lectins.与大豆和花生凝集素结合的淋巴细胞表面糖蛋白。
Immunology. 1982 Aug;46(4):713-26.
8
Binding of peanut lectin to germinal-centre cells: a marker for B-cell subsets of follicular lymphoma?花生凝集素与生发中心细胞的结合：滤泡性淋巴瘤B细胞亚群的标志物？
Br J Cancer. 1981 Jul;44(1):68-74. doi: 10.1038/bjc.1981.149.
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Cell Tissue Res. 1984;238(1):183-9. doi: 10.1007/BF00215160.
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Lectin-binding spectra in the hyperplastic human tonsil. Effect of formalin fixation and paraffin embedding on lectin affinity of tissue components.人增生性扁桃体中的凝集素结合谱。福尔马林固定和石蜡包埋对组织成分凝集素亲和力的影响。
Histochemistry. 1984;81(6):551-60. doi: 10.1007/BF00489534.
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Immunochemical studies on the specificity of the peanut (Arachis hypogaea) agglutinin.花生（落花生）凝集素特异性的免疫化学研究。
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Eur J Immunol. 1979 Feb;9(2):139-45. doi: 10.1002/eji.1830090209.