Ramos C P, Almario J S
Makati Medical Center, Philippines.
Biomater Artif Cells Artif Organs. 1990;18(5):689-92. doi: 10.3109/10731199009117338.
It is theorized that charcoal hemoperfusion and hemodialysis with a highly permeable membrane should be synergistic in the management of fulminant hepatic failure. Previous studies have shown marked differences between these two treatments in their effects in the various biochemical abnormalities of this serious clinical problem. Survival rates in patients treated with charcoal hemoperfusion approximate the rates in those treated with hemodialysis with a highly permeable membrane but are only slightly better than in untreated cases. The excellent recovery of two patients with fulminant viral hepatitis in stage III and IV coma treated with this combined regimen indicates that further studies should be done to confirm this thesis.
理论上认为，在暴发性肝衰竭的治疗中，木炭血液灌流和使用高通透性膜的血液透析应具有协同作用。先前的研究表明，这两种治疗方法在解决这一严重临床问题的各种生化异常方面效果存在显著差异。接受木炭血液灌流治疗的患者生存率与接受高通透性膜血液透析治疗的患者相近，但仅略高于未治疗的病例。两名处于III期和IV期昏迷的暴发性病毒性肝炎患者采用这种联合治疗方案后实现了良好康复，这表明应进一步开展研究以证实这一论点。
