一种用于尿毒症血液灌流的新型包膜活性炭的评估。

Evaluation of a new coated charcoal for hemoperfusion in uremia.

作者信息

Stefoni S, Feliciangeli G, Coli L, Bonomini V

出版信息

Int J Artif Organs. 1979 Nov;2(6):320-3.

Abstract

A new coated charcoal for hemoperfusion in uremia was investigated in 14 patients with end stage renal disease who underwent hemoperfusion or combined hemodialysis-hemoperfusion (39 seances). Investigations concerned removal of small molecules, coagulation and hematological status and amino acids and some hormones equilibrium. Clinical observations were also made in all patients. The methacrylate-coated charcoal enabled the removal of "toxins" up to 5000 daltons and the total solute removal did not significantly differ from previous hemoperfusion systems. However, the new coating membrane showed improved biocompatibility, in terms of clinical side effects and/or platelet and fibrinogen alterations.

摘要

对一种用于尿毒症血液灌流的新型包膜活性炭进行了研究，研究对象为14例终末期肾病患者，他们接受了血液灌流或血液透析-血液灌流联合治疗（共39次疗程）。研究内容包括小分子的清除、凝血及血液学状态以及氨基酸和一些激素的平衡。还对所有患者进行了临床观察。甲基丙烯酸酯包膜活性炭能够清除分子量达5000道尔顿的“毒素”，且总溶质清除率与以往的血液灌流系统相比无显著差异。然而，就临床副作用和/或血小板及纤维蛋白原的改变而言，这种新型包膜膜显示出更好的生物相容性。