Corbett T H, Simmons J L, Kawanishi H, Endres J L
Environ Health Perspect. 1978 Apr;23:275-81. doi: 10.1289/ehp.7823275.
Groups of Swiss ICR mice were fed 1000 ppm polybrominated biphenyls (FireMaster BP-6) in rodent chow for 4, 8, 11, and 14 days. Control groups were fed standard rodent chow without FireMaster BP-6. Animals were killed at the end of each feeding period and the livers examined by electron microscopy. EM changes noted were progressive increase in size of hepatocytes, a decrease in rough endoplasmic reticulum, a marked increase in smooth endoplasmic reticulum, mitochondrial degeneration, increased lysosomes, and a decrease in glycogen. In addition, there was increasing proliferation of microvilli in bile canaliculi with increasing feeding times. A group of mice fed 1000 ppm FireMaster BP-6 in rodent chow for 11 days had livers with a mean of 13.93% of total body weight as compared with 6.49% for the control group (P=0.02). Tissue distribution following ingestion of 100 ppm FireMaster BP-6 for 14 days was studied. Twelve weeks post-feeding, the tissue concentrations of hexabromobiphenyl in order of highest concentration to lowest were as follows: perithymic fat, perirenal fat, adrenal glands, thymus gland, liver and stomach.
将瑞士ICR小鼠分组，在啮齿动物饲料中喂食1000 ppm的多溴联苯（FireMaster BP - 6），持续4天、8天、11天和14天。对照组喂食不含FireMaster BP - 6的标准啮齿动物饲料。在每个喂食期结束时处死动物，并通过电子显微镜检查肝脏。观察到的电子显微镜变化包括肝细胞大小逐渐增加、粗面内质网减少、滑面内质网显著增加、线粒体变性、溶酶体增加以及糖原减少。此外，随着喂食时间的增加，胆小管中的微绒毛增殖也在增加。一组在啮齿动物饲料中喂食1000 ppm FireMaster BP - 6 11天的小鼠，其肝脏平均占总体重的13.93%，而对照组为6.49%（P = 0.02）。研究了摄入100 ppm FireMaster BP - 6 14天后的组织分布情况。喂食12周后，六溴联苯在组织中的浓度从高到低依次为：胸腺周围脂肪、肾周脂肪、肾上腺、胸腺、肝脏和胃。
