Aulerich R J, Ringer R K
Arch Environ Contam Toxicol. 1979;8(4):487-98. doi: 10.1007/BF01056355.
Serial levels of fireMaster FF-1, a commercial mixture of polybrominated biphenyls (PBB), and tissues from chickens and a cow that had previously consumed PBB were fed to mink to ascertain the chronic effects of the commercial and "metabolized" form of this compound on mink. Diets that contained 6.25 ppm (or more) PBB were lethal to adult mink within 10 months. One to 2.5 ppm dietary PBB fed for 9 months had an adverse effect on litter size, kit weight at birth, and kit survival. The data suggest that the PBB derived from contaminated beef and poultry was more toxic than the original PBB. The clinical signs of PBB poisoning in mink were food rejection, weight loss, and unthrifty appearance, and fatty infiltration of the liver. Based on these findings, mink must be considered highly susceptible to PBB toxicity. PBB residue levels 60 times the amount in the diet were found in the adipose tissue of the PBB-treated animals.
连续测定了FireMaster FF - 1（一种多溴联苯（PBB）的商业混合物）的含量，并将此前食用过PBB的鸡和牛的组织喂给水貂，以确定这种化合物的商业形式和“代谢”形式对水貂的慢性影响。含有6.25 ppm（或更高）PBB的日粮在10个月内对成年水貂具有致死性。喂食1至2.5 ppm日粮PBB 9个月对产仔数、幼崽出生体重和幼崽存活率有不利影响。数据表明，来自受污染牛肉和家禽的PBB比原始PBB毒性更大。水貂PBB中毒的临床症状为拒食、体重减轻、外观消瘦以及肝脏脂肪浸润。基于这些发现，必须认为水貂对PBB毒性高度敏感。在接受PBB处理的动物的脂肪组织中发现PBB残留水平是日粮中含量的60倍。
