Kimbrough R D, Burse V W, Liddle J A
Environ Health Perspect. 1978 Apr;23:265-73. doi: 10.1289/ehp.7823265.
In a preliminary study, 12 male and 12 female weanling Sherman strain rats were given a single dose of 1000 mg polybrominated biphenyls (PBBs) FireMaster FF1 Lot 7042 kg/body weight as a 5% solution in corn oil. Three male and three female weanling rats were given corn oil. One day after dosing PBB blood levels ranged from 78 to 162 ppm and 42 days later they ranged from 1.1 to 2.99 ppm. The liver was the only organ with pathological changes. In a long-term recovery study groups of 20 male and female rats, 2 months old, were given 0 or 1000 mg PBBs/kg body weight as a single dose in peanut oil. Five rats per group killed 2, 6, 10, and 14 months after dosing had pronounced liver pathology, including hepatic porphyria in the female rats and neoplastic nodules also mainly in female rats. Chemical analyses of blood, liver, and adipose tissue for PPBs 10 and 14 months after dosing gave the following mean results. Blood levels in females were 2.9 and 2.92 ppm, respectively, and males 0.94 and 1.34 ppm, respectively. Adipose tissue levels in females were 1202 and 783 ppm and in males 713 and 866 ppm, respectively. The liver levels in females were 37 and 22 ppm and in males 60 and 63 ppm, respectively.
在一项初步研究中，给12只雄性和12只雌性断乳期的谢尔曼品系大鼠单次经口灌胃1000毫克多溴联苯（PBBs）FireMaster FF1批次7042，剂量为5%玉米油溶液/体重。给3只雄性和3只雌性断乳期大鼠灌胃玉米油。给药后1天，PBB血液浓度范围为78至162 ppm，42天后，其范围为1.1至2.99 ppm。肝脏是唯一出现病理变化的器官。在一项长期恢复性研究中，给20只2月龄的雄性和雌性大鼠，以花生油单次经口灌胃0或1000毫克PBBs/体重。给药后2、6、10和14个月每组处死5只大鼠，发现有明显的肝脏病变，包括雌性大鼠的肝卟啉症，以及主要也在雌性大鼠中的肿瘤结节。给药后10个月和14个月对血液、肝脏和脂肪组织进行多溴联苯的化学分析，得出以下平均结果。雌性大鼠血液浓度分别为2.9和2.92 ppm，雄性大鼠分别为0.94和1.34 ppm。雌性大鼠脂肪组织浓度分别为1202和783 ppm，雄性大鼠分别为713和866 ppm。雌性大鼠肝脏浓度分别为37和22 ppm，雄性大鼠分别为60和63 ppm。
