Aguilar L, Esteban C, Frias J, Pérez-Balcabao I, Carcas A J, Dal-Ré R
Medical Department, SmithKline Beecham Pharmaceuticals, Madrid, Spain.
J Antimicrob Chemother. 1994 Jan;33(1):91-101. doi: 10.1093/jac/33.1.91.
Plasma concentration of cefminox and serum bactericidal activity against four ATCC strains (Escherichia coli 25992, Klebsiella pneumoniae 13833, Serratia marcescens 8100 and Bacteroides fragilis 25285), were determined over a 24 h period after administration of cefminox 1 and 2 g to six healthy volunteers in a randomized, cross-over, single blind study. The increase observed in the area under the bactericidal curve (AUBC) with the 2 g dose was at least 3.5 times that seen with the 1 g dose for all four test strains and was larger than predicted by the corresponding increase (1.84 times) in the area under the serum concentration versus time curve (AUC); a correlation (r = 0.88, P = 0.0001) between the cefminox concentration and the serum bactericidal titres was, however, observed with all four strains tested. The MBC6h showed a better association with the serum bactericidal titre (P < 0.01) than did the MIC or MBC.
在一项随机、交叉、单盲研究中，对6名健康志愿者给予1克和2克头孢米诺后，在24小时内测定了头孢米诺的血浆浓度以及针对四种美国典型培养物保藏中心菌株（大肠埃希菌25992、肺炎克雷伯菌13833、粘质沙雷菌8100和脆弱拟杆菌25285）的血清杀菌活性。对于所有四种测试菌株，2克剂量组杀菌曲线下面积（AUBC）的增加至少是1克剂量组的3.5倍，且大于血清浓度-时间曲线下面积（AUC）相应增加（1.84倍）所预测的值；然而，在所有四种测试菌株中均观察到头孢米诺浓度与血清杀菌效价之间存在相关性（r = 0.88，P = 0.0001）。与最低抑菌浓度（MIC）或最低杀菌浓度（MBC）相比，6小时最低杀菌浓度（MBC6h）与血清杀菌效价的相关性更好（P < 0.01）。
