Wagay A R, Singhal K C, Bhargava R
Department of Pharmacology, J.N. Medical College, A.M.U., Aligarh.
Indian J Physiol Pharmacol. 1990 Oct;34(4):259-62.
20 Patients of tuberculous pleural effusion were administered a combination of pyrazinamide (30 mg/kg) + isoniazid (300 mg) orally for 7 consecutive days and pyrazinamide was estimated by spectrophotometric method in serum and pleural fluid. Prednisolone was added to the above regimen for next 7 consecutive days and pyrazinamide was again estimated. The level of pyrazinamide in pleural fluid was 23.4 +/- 1.2 (micrograms/ml). Following addition of prednisolone the level increased (27.6 +/- 1.3) significantly (P less than 0.001). The serum pyrazinamide level was not influenced by simultaneous administration of prednisolone. The pleural fluid/serum pyrazinamide ratio was increased from 0.465 to 0.542 by the addition of prednisolone to therapeutic regimen.
对20例结核性胸腔积液患者连续7天口服吡嗪酰胺（30mg/kg）+异烟肼（300mg）联合用药，并采用分光光度法测定血清和胸腔积液中的吡嗪酰胺含量。接下来连续7天在上述治疗方案中加入泼尼松龙，并再次测定吡嗪酰胺含量。胸腔积液中吡嗪酰胺水平为23.4±1.2（微克/毫升）。加入泼尼松龙后，该水平显著升高（27.6±1.3）（P＜0.001）。同时服用泼尼松龙对血清吡嗪酰胺水平无影响。治疗方案中加入泼尼松龙后，胸腔积液/血清吡嗪酰胺比值从0.465增至0.542。
