Blair D F
Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138.
Semin Cell Biol. 1990 Apr;1(2):75-85.
The bacterial flagellar motor is a remarkable molecular machine that converts chemical energy into work. Knowledge of the structure, genetics, and dynamics of the motor has expanded steadily. Recent progress is reviewed, with an emphasis on the dynamics of flagellar rotation. Previous results with tethered cells, which rotate slowly, are contrasted with recent work on swimming cells, whose motors turn very rapidly. Genetic evidence delineates a small set of proteins that are likely to participate directly in the process of torque generation. An explicit hypothesis for torque generation is described, in which roles are envisaged for each of these proteins.
细菌鞭毛马达是一种卓越的分子机器，可将化学能转化为功。对该马达的结构、遗传学和动力学的认识一直在稳步扩展。本文综述了近期的进展，重点是鞭毛旋转的动力学。先前对 tethered 细胞（旋转缓慢）的研究结果与近期对游动细胞（其马达旋转非常迅速）的研究形成对比。遗传学证据明确了一小部分可能直接参与扭矩产生过程的蛋白质。文中描述了一个关于扭矩产生的明确假说，其中设想了每种蛋白质的作用。
