Buxton D
J Med Microbiol. 1978 Aug;11(3):289-92. doi: 10.1099/00222615-11-3-289.
Mice were given an intravenous dose of formalinised C. welchii type-D epsilon prototoxin and an immunoperoxidase technique was used to demonstrate this antigen in the tissues. The antigen was found to bind to the luminal surface of the endothelial lining of certain blood vessels, to the luminal surface of the cells lining the loops of Henlé and distal convoluted tubules in the kidney, and to the hepatic sinusoids. As it has been shown previously that formalinised epsilon prototoxin and epsilon toxin can compete for the same receptor sites it is postulated that the binding sites demonstrated represent the location of the receptors for C. welchii type-D epsilon toxin.
给小鼠静脉注射福尔马林固定的D型魏氏梭菌ε原毒素，并用免疫过氧化物酶技术在组织中显示该抗原。发现该抗原与某些血管内皮衬里的管腔表面、肾亨利氏袢和远曲小管内衬细胞的管腔表面以及肝血窦结合。由于先前已表明福尔马林固定的ε原毒素和ε毒素可竞争相同的受体位点，因此推测所显示的结合位点代表D型魏氏梭菌ε毒素受体的位置。
