Crouch C F, Woode G N
J Med Microbiol. 1978 Aug;11(3):325-34. doi: 10.1099/00222615-11-3-325.
A serial study of rotavirus infection in gnotobiotic piglets is described. They were infected when 7 days old and the course of infection was followed for 21 days, by immunofluorescence and histological examinations of the intestinal epithelium and by titration of the virus content of the gut lumen. There appeared to be two stages of recovery of the intestinal wall, the earlier stage involving non-immune mechanisms and the later invloving antibody.
本文描述了对无菌仔猪轮状病毒感染的系列研究。仔猪在7日龄时被感染，并通过对肠上皮进行免疫荧光和组织学检查以及对肠腔病毒含量进行滴定，对感染过程进行了21天的跟踪观察。肠壁的恢复似乎有两个阶段，早期阶段涉及非免疫机制，后期阶段涉及抗体。
