Department of Human Anatomy, Faculty of Pharmacy and Biochemistry, INFIBIOC, Buenos Aires, Argentina.
Clin Exp Hypertens. 2010;32(7):453-7. doi: 10.3109/10641961003686443.
This study analyzes the effects of sodium tungstate and vanadyl sulphate in the fructose-overloaded rat, a model of metabolic syndrome. Fructose (9 weeks) increased blood pressure, triglycerydemia, glycemia, and reduced release of vasodilator prostaglandins (prostacyclin and prostaglandin E2 ) in the mesenteric vascular bed. Sodium tungstate prevented those alterations; meanwhile vanadyl sulfate only prevented the increase in glycemia. In conclusion, the present experiments showed that sodium tungstate is more effective than vanadyl sulfate for the treatment of experimental metabolic syndrome in rats.
本研究分析了钨酸钠和硫酸氧钒在果糖超负荷大鼠（代谢综合征模型）中的作用。果糖（9 周）可引起血压升高、甘油三酯升高、血糖降低和肠系膜血管床舒张性前列腺素（前列环素和前列腺素 E2）释放减少。钨酸钠可预防这些改变；而硫酸氧钒仅可预防血糖升高。总之，本实验表明，钨酸钠在治疗大鼠实验性代谢综合征方面比硫酸氧钒更有效。
