Institute for Research in Biomedicine, Bellinzona, Switzerland.
Cell. 2010 Oct 29;143(3):339-40. doi: 10.1016/j.cell.2010.10.022.
Dendritic cells are professional antigen-presenting cells that mediate immunity and tolerance. Cheong et al. (2010) uncover a new route for dendritic cell production in vivo. They show that in response to infection by gram-negative bacteria, monocytes are recruited to the lymph node where they rapidly differentiate into dendritic cells that present antigens to T cells.
树突状细胞是专业的抗原呈递细胞,它们在调节免疫和耐受中发挥作用。Cheong 等人(2010 年)揭示了树突状细胞在体内生成的新途径。他们发现,革兰氏阴性菌感染后,单核细胞被募集到淋巴结,在那里它们迅速分化为树突状细胞,将抗原呈递给 T 细胞。