Department of Behavioral Medicine Research, Baystate Medical Center, Springfield, MA 01105, USA.
J Clin Densitom. 2010 Oct-Dec;13(4):392-8. doi: 10.1016/j.jocd.2010.07.006.
Total body mass is a major determinant of bone mass, but studies of the relative contributions of lean mass (LM) and fat mass (FM) to bone mass have yielded conflicting results. This is likely because of the use of bone measures that are not adequately adjusted for body size and, therefore, not appropriate for analyses related to body composition, which is also correlated with body size. We examined the relationship between body composition and peak bone mass in premenopausal women aged 18-30 yr using both size-dependent and size-adjusted measures of bone density and body composition, as well as statistical models adjusted for size-related factors. We measured total bone mass and areal bone density using dual-energy X-ray absorptiometry, and used established formulas to calculate estimates of volumetric (size-adjusted) bone density. LM tended to be positively associated with bone both before and after adjustment for size-related factors. FM and body fat percentage, however, were positively associated with size-dependent bone measures, but adjusting for size removed or reversed this association. These findings suggest that the association between bone mass and body composition, especially FM, is dependent on the bone measures analyzed, and that determining the most appropriate size-adjustment techniques is critical for understanding this relationship.
总体体重是骨量的主要决定因素，但对瘦体重（LM）和脂肪量（FM）对骨量的相对贡献的研究得出了相互矛盾的结果。这可能是因为使用了不能充分调整体型的骨骼测量值，因此不适合与身体成分相关的分析，而身体成分也与体型相关。我们使用依赖体型和调整体型的骨密度和身体成分测量值以及针对与体型相关的因素进行调整的统计模型，研究了 18-30 岁的绝经前妇女的身体成分与峰值骨量之间的关系。我们使用双能 X 射线吸收法测量总骨量和面积骨密度，并使用既定公式计算体积（调整体型）骨密度的估计值。在调整与体型相关的因素之前和之后，LM 往往与骨骼呈正相关。然而，FM 和体脂百分比与依赖体型的骨骼测量值呈正相关，但调整体型会消除或逆转这种关联。这些发现表明，骨量与身体成分之间的关联，尤其是 FM，取决于所分析的骨骼测量值，确定最合适的体型调整技术对于理解这种关系至关重要。
