Lindsay R, Cosman F, Herrington B S, Himmelstein S
Regional Bone Center, Helen Hayes Hospital, West Haverstraw, New York.
J Bone Miner Res. 1992 Jan;7(1):55-63. doi: 10.1002/jbmr.5650070109.
The interrelationships between measurements of bone mass and total-body bone mineral were examined in a cross-sectional study of normal healthy women aged 17-82 years. In addition we evaluated the relationship between measures of body composition, estimated by four independent techniques, and bone mass in the same population. Considering the group as a whole, bone mass at all sites correlated with each other and with total-body bone mineral (TBBM). Cancellous and cortical sites could predict TBBM equally well. As expected, all measurements of bone mass were significantly lower in postmenopausal women in comparison to premenopausal women. Declines in bone mass were only seen in premenopausal women in the femoral neck and Ward's triangle, not in lumbar spine, radius, or skeleton as a whole. In postmenopausal women bone mass correlated negatively with age and years from menopause equally at all sites. TBBM was significantly related to height and weight in both premenopausal and postmenopausal women. In premenopausal and postmenopausal women TBBM also correlated with fat mass, but TBBM was much better correlated with percentage body fat in premenopausal than postmenopausal women. TBBM was a constant proportion of lean body mass in premenopausal women, but the fraction of lean mass occupied by the skeleton declined with age in postmenopausal women. Correction of TBBM for lean mass did not change the relationship between TBBM and percentage fat in premenopausal women but eliminated the relationship in postmenopausal women. Regional measurements, which are at least partially corrected for body size by dividing mass by area, correlated less well with height and weight and with any index of obesity, especially in postmenopausal women.
在一项针对17至82岁正常健康女性的横断面研究中，对骨量测量值与全身骨矿物质之间的相互关系进行了研究。此外，我们还评估了通过四种独立技术估算的身体成分测量值与同一人群骨量之间的关系。从整体来看，所有部位的骨量彼此之间以及与全身骨矿物质（TBBM）均存在相关性。松质骨和皮质骨部位对TBBM的预测效果相当。正如预期的那样，与绝经前女性相比，绝经后女性的所有骨量测量值均显著更低。仅在绝经前女性的股骨颈和沃德三角区观察到骨量下降，而在腰椎、桡骨或整个骨骼中未观察到。在绝经后女性中，所有部位的骨量均与年龄以及绝经后的年限呈负相关。在绝经前和绝经后女性中，TBBM均与身高和体重显著相关。在绝经前和绝经后女性中，TBBM也与脂肪量相关，但与绝经前女性相比，绝经后女性的TBBM与体脂百分比的相关性更强。在绝经前女性中，TBBM占瘦体重的比例恒定，但在绝经后女性中，骨骼所占瘦体重的比例随年龄下降。对绝经前女性的TBBM进行瘦体重校正后，并未改变TBBM与体脂百分比之间的关系，但消除了绝经后女性中的这种关系。通过将质量除以面积对身体大小进行至少部分校正后的区域测量值，与身高、体重以及任何肥胖指数的相关性较差，尤其是在绝经后女性中。
