婴幼儿甲型流感感染。

Influenza A infection in young infants.

机构信息

Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus, Israel.

出版信息

Arch Dis Child. 2011 Nov;96(11):1085-7. doi: 10.1136/adc.2010.182873. Epub 2010 Oct 27.

DOI:10.1136/adc.2010.182873

PMID:21030378

Abstract

OBJECTIVE

To determine the clinical characteristics of infants ≤2 months old hospitalised with influenza A.

STUDY DESIGN

The study was a retrospective analysis of infants ≤2 months old hospitalised with fever, respiratory distress and/or sepsis. Clinical signs, laboratory values, hospital duration and outcome were compared between children with influenza A and other viruses.

RESULTS

The charts of 268 infants were reviewed. 29 (11%) children had laboratory-confirmed influenza A infection. Unique features associated with influenza infection included the high number presenting with fever (97%) and a history of exposure to family members with a flu-like illness (69%). A significantly lower rate of respiratory distress was observed in the influenza group compared with respiratory syncytial virus (RSV) (24% vs 89%, p≤0.001). Median duration of hospitalisation for influenza was shorter than RSV (4 days vs 6 days, p<0.001).

CONCLUSIONS

In young infants, influenza A is a relatively mild disease compared to RSV and is primarily associated with upper respiratory tract manifestations.

摘要

目的

明确 2 月龄以下因甲型流感住院患儿的临床特征。

设计

本研究为回顾性分析，纳入因发热、呼吸窘迫和/或脓毒症住院的 2 月龄以下婴儿。比较甲型流感患儿与其他病毒患儿的临床特征、实验室检查结果、住院时间和结局。

结果

共纳入 268 例患儿，29 例（11%）患儿经实验室检查确诊为甲型流感感染。甲型流感感染的特征性表现包括：发热比例高（97%）和与流感样症状的家庭成员接触史（69%）。与呼吸道合胞病毒（RSV）相比，甲型流感患儿呼吸窘迫的发生率显著更低（24%比 89%，p≤0.001）。甲型流感患儿的住院时间中位数短于 RSV（4 天比 6 天，p<0.001）。