Department of Psychology, Princeton University, Princeton, NJ 08540, USA.
Soc Cogn Affect Neurosci. 2011 Oct;6(5):572-81. doi: 10.1093/scan/nsq086. Epub 2010 Oct 28.
We explored the neural correlates of learning about people when the affective value of both facial appearance and behavioral information is manipulated. Participants were presented with faces that were either rated as high or low on trustworthiness. Subsequently, we paired these faces with positive, negative, or no behavioral information. Prior to forming face-behavior associations, a cluster in the right amygdala responded more strongly to untrustworthy than to trustworthy faces. During learning, a cluster in the dorsomedial prefrontal cortex (dmPFC) responded more strongly to faces paired with behaviors than faces not paired with behaviors. We also observed that the activity in the dmPFC was correlated with behavioral learning performance assessed after scanning. Interestingly, individual differences in the initial amygdala response to face trustworthiness prior to learning modulated the relationship between dmPFC activity and learning. This finding suggests that the activity of the amygdala can affect the interaction between dmPFC activity and learning.
我们探讨了在操纵面部外观和行为信息的情感价值的情况下，了解他人的神经相关性。参与者被呈现出被评为高或低可信度的面孔。随后，我们将这些面孔与积极、消极或无行为信息进行配对。在形成面孔-行为关联之前，右侧杏仁核中的一个簇对不可信的面孔比对可信的面孔反应更强烈。在学习过程中，背内侧前额叶皮层（dmPFC）中的一个簇对与行为配对的面孔的反应比未与行为配对的面孔更强烈。我们还观察到，dmPFC 的活动与扫描后评估的行为学习表现相关。有趣的是，在学习之前，杏仁核对面孔可信度的初始反应的个体差异调节了 dmPFC 活动和学习之间的关系。这一发现表明，杏仁核的活动可以影响 dmPFC 活动和学习之间的相互作用。
