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Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma.Toll样受体4基因多态性与正常眼压性青光眼的关联
Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4453-7. doi: 10.1167/iovs.07-1575. Epub 2008 Jun 27.
2
Risk factors for open-angle glaucoma in a Japanese population: the Tajimi Study.日本人群开角型青光眼的危险因素：多治见研究
Ophthalmology. 2006 Sep;113(9):1613-7. doi: 10.1016/j.ophtha.2006.03.059. Epub 2006 Jul 7.
3
The number of people with glaucoma worldwide in 2010 and 2020.2010年和2020年全球青光眼患者人数。
Br J Ophthalmol. 2006 Mar;90(3):262-7. doi: 10.1136/bjo.2005.081224.
4
Autoimmunity against neurofilament protein and its possible association with HLA-DRB1*1502 allele in glaucoma.青光眼患者中针对神经丝蛋白的自身免疫及其与HLA - DRB1*1502等位基因的可能关联。
Immunol Lett. 2005 Sep 15;100(2):164-9. doi: 10.1016/j.imlet.2005.03.017.
5
The prevalence of primary open-angle glaucoma in Japanese: the Tajimi Study.日本原发性开角型青光眼的患病率：多治见研究
Ophthalmology. 2004 Sep;111(9):1641-8. doi: 10.1016/j.ophtha.2004.03.029.
6
Heat shock proteins, immunity and glaucoma.热休克蛋白、免疫与青光眼。
Brain Res Bull. 2004 Feb 15;62(6):473-80. doi: 10.1016/S0361-9230(03)00074-1.
7
PyPop: a software framework for population genomics: analyzing large-scale multi-locus genotype data.PyPop：一个用于群体基因组学的软件框架：分析大规模多位点基因型数据。
Pac Symp Biocomput. 2003:514-25.
8
Antiphosphatidylserine antibodies are elevated in normal tension glaucoma.在正常眼压性青光眼中，抗磷脂酰丝氨酸抗体水平升高。
Clin Exp Immunol. 2001 Aug;125(2):211-5. doi: 10.1046/j.1365-2249.2001.01578.x.
9
Risk factors for progression of visual field abnormalities in normal-tension glaucoma.正常眼压性青光眼中视野异常进展的危险因素。
Am J Ophthalmol. 2001 Jun;131(6):699-708. doi: 10.1016/s0002-9394(01)00964-3.
10
Serum autoantibody against glutathione S-transferase in patients with glaucoma.青光眼患者血清中抗谷胱甘肽S-转移酶自身抗体
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日本正常眼压性青光眼患者的HLA - DRB1和HLA - DQB1等位基因分型

Genotyping HLA-DRB1 and HLA-DQB1 alleles in Japanese patients with normal tension glaucoma.

作者信息

Suzuki Misa, Meguro Akira, Ota Masao, Nomura Eiichi, Kato Tetsuo, Nomura Naoko, Kashiwagi Kenji, Mabuchi Fumihiko, Iijima Hiroyuki, Kawase Kazuhide, Yamamoto Tetsuya, Nakamura Makoto, Negi Akira, Sagara Takeshi, Nishida Teruo, Inatani Masaru, Tanihara Hidenobu, Aihara Makoto, Araie Makoto, Fukuchi Takeo, Abe Haruki, Higashide Tomomi, Sugiyama Kazuhisa, Kanamoto Takashi, Kiuchi Yoshiaki, Iwase Aiko, Ohno Shigeaki, Inoko Hidetoshi, Mizuki Nobuhisa

机构信息

Department of Ophthalmology and Visual Science Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.

出版信息

Mol Vis. 2010 Sep 15;16:1874-9.

PMID:21031025
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2956698/
Abstract

PURPOSE

Normal tension glaucoma (NTG) is a subtype of glaucoma in which intraocular pressure is within the statistically normal range. NTG may be associated with an immune disorder. The aim of this study was to determine whether specific alleles in the human leukocyte antigen (HLA)-DRB1 and HLA-DQB1 genes correlated with NTG in Japanese patients.

METHODS

We genotyped the HLA-DRB1 and HLA-DQB1 alleles in 113 Japanese patients with NTG and in 184 healthy Japanese control subjects using the polymerase chain reaction-sequence-specific oligonucleotide probes (PCR-SSOP) Luminex method. We assessed the allelic diversity in patients and controls.

RESULTS

There were no statistically significant differences in the allele frequency of HLADRB1 and HLA-DQB1 between NTG patients and control subjects, and no HLA-DRB1-HLA-DQB1 haplotypes demonstrated any significant association with NTG.

CONCLUSIONS

Our findings suggest that HLA-DRB1 and HLA-DQB1 polymorphisms have no significant effect on the development of NTG in Japanese patients.

摘要

目的

正常眼压性青光眼（NTG）是青光眼的一种亚型，其眼压在统计学正常范围内。NTG可能与免疫紊乱有关。本研究的目的是确定人类白细胞抗原（HLA）-DRB1和HLA-DQB1基因中的特定等位基因是否与日本患者的NTG相关。

方法

我们使用聚合酶链反应-序列特异性寡核苷酸探针（PCR-SSOP）Luminex方法对113例日本NTG患者和184例健康日本对照者的HLA-DRB1和HLA-DQB1等位基因进行基因分型。我们评估了患者和对照者的等位基因多样性。

结果

NTG患者与对照者之间HLA-DRB1和HLA-DQB1的等位基因频率无统计学显著差异，且没有HLA-DRB1-HLA-DQB1单倍型显示与NTG有任何显著关联。

结论

我们的研究结果表明，HLA-DRB1和HLA-DQB1多态性对日本患者NTG的发生没有显著影响。