Kremmer S, Kreuzfelder E, Klein R, Bontke N, Henneberg-Quester K B, Steuhl K P, Grosse-Wilde H
Abteilung für Erkrankungen des vorderen Augenabschnittes, Universitätsklinikum Essen, Germany.
Clin Exp Immunol. 2001 Aug;125(2):211-5. doi: 10.1046/j.1365-2249.2001.01578.x.
The two main entities of open-angle glaucoma are primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG). Both diseases may be associated with autoimmune processes. Therefore, IgG and IgM antibodies to phospholipids (APL) and their subspecies cardiolipin (ACL), phosphatidylserine (APS) and beta2-glycoprotein (beta2GP) were determined in 43 NTG patients, 40 POAG patients and 40 healthy controls in a prospective study. The most prominent observation was the increase in APS concentrations in NTG patients (IgG 20.6 +/- 2.7 U/ml, IgM 24.4 +/- 3.4 U/ml) compared with POAG patients (IgG 8.8 +/- 1.2 U/ml, IgM 11.0 +/- 1.7), and controls (IgG 7.7 +/- 1.3 U/ml, IgM 12.8 +/- 1.5 U/ml). APS may be important due to their binding specificity to phosphatidylserine molecules which become accessible during apoptosis; this in turn may lead to local thrombosis.
开角型青光眼的两个主要类型是原发性开角型青光眼（POAG）和正常眼压性青光眼（NTG）。这两种疾病都可能与自身免疫过程有关。因此，在一项前瞻性研究中，对43例NTG患者、40例POAG患者和40名健康对照者检测了针对磷脂（APL）及其亚型心磷脂（ACL）、磷脂酰丝氨酸（APS）和β2糖蛋白（β2GP）的IgG和IgM抗体。最显著的观察结果是，与POAG患者（IgG 8.8±1.2 U/ml，IgM 11.0±1.7）和对照者（IgG 7.7±1.3 U/ml，IgM 12.8±1.5 U/ml）相比，NTG患者的APS浓度升高（IgG 20.6±2.7 U/ml，IgM 24.4±3.4 U/ml）。由于APS与凋亡过程中可暴露的磷脂酰丝氨酸分子具有结合特异性，因此可能很重要；这反过来可能导致局部血栓形成。
