Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom.
J Magn Reson Imaging. 2010 Nov;32(5):1242-7. doi: 10.1002/jmri.22340.
To investigate whether a 3D-modified driven equilibrium Fourier transform (MDEFT)-based acquisition protocol established for brain morphometry also yields reliable information about the cross-sectional spinal cord area (SCA).
Images of brain and cervical cord of 10 controls and eight subjects with spinal cord injury (SCI) were acquired with the 3D-MDEFT-based imaging protocol and an 8-channel receive head coil. The new protocol was validated by two observers 1) comparing the SCA measured with the standard acquisition protocol (3D magnetization-prepared rapid acquisition gradient echo [MPRAGE] and dedicated spine coil) and the new protocol; and 2) determining the scan-rescan reproducibility of the new protocol.
Scan-rescan reproducibility of SCA measurements with the MDEFT approach showed a similar precision for both observers with standard deviation (SD) <4.5 mm(2) and coefficient of variation (CV) ≤5.1%. Analysis of variance (ANOVA) revealed a main effect of observer and interaction between observer and scan protocol that could be primarily attributed to a small observer bias for MPRAGE (difference in SCA <2.1 mm(2)). No bias was observed for 3D-MDEFT vs. 3D-MPRAGE.
The 3D-MDEFT method allows for robust unbiased assessment of SCA in addition to brain morphology.
研究基于三维修正驱动平衡傅里叶变换（MDEFT）的脑形态测量采集方案是否也能提供关于脊髓横截面积（SCA）的可靠信息。
10 例健康对照者和 8 例脊髓损伤（SCI）患者的脑和颈髓图像采用基于 3D-MDEFT 的成像方案和 8 通道接收线圈进行采集。新方案通过两位观察者进行了验证：1）比较标准采集方案（3D 磁化准备快速获取梯度回波[MPRAGE]和专用脊柱线圈）和新方案测量的 SCA；2）确定新方案的扫描-再扫描可重复性。
MDEFT 方法测量 SCA 的扫描-再扫描可重复性对于两位观察者具有相似的精度，标准偏差（SD）<4.5mm2，变异系数（CV）≤5.1%。方差分析（ANOVA）显示观察者和扫描方案之间存在主要交互作用，这主要归因于 MPRAGE 的观察者偏倚较小（SCA 差异<2.1mm2）。与 3D-MPRAGE 相比，3D-MDEFT 没有观察到偏差。
除了脑形态学外，3D-MDEFT 方法还可以对 SCA 进行稳健、无偏的评估。
