冠心病患者血清高敏C反应蛋白水平与冠状动脉狭窄程度的关系
Relationship between high-sensitivity C-reactive protein serum levels and the severity of coronary artery stenosis in patients with coronary artery disease.
作者信息
Seyedian Seyed Masoud, Ahmadi Farzaneh, Dabagh Razieh, Davoodzadeh Hannaneh
机构信息
Assistant Professor, Atherosclerosis Research Center AND Department of Cardiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Assistant Professor, Echocardiography Fellowship, Atherosclerosis Research Center AND Department of Cardiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
出版信息
ARYA Atheroscler. 2016 Sep;12(5):231-237.
BACKGROUND
High-sensitivity C-reactive protein (hs-CRP) inflammatory biomarker is one of the best informative markers of prognosis of coronary artery disease (CAD) that has been studied. Some studies have found that hs-CRP has a direct correlation with CAD. The aim of this study was to determine the relationship between serum levels of hs-CRP and the severity of coronary artery stenosis in patients with stable and unstable angina.
METHODS
In a cross-sectional study, 150 patients undergoing coronary angiography in Golestan Hospital Ahvaz, Iran in 2012, were studied in three groups of stable angina (n = 50), unstable angina (n = 50), and normal coronary angiography (n = 50). Hs-CRP levels were measured in patients before angiography by enzyme-linked immunosorbent assay method, were compared between the three groups and its correlation with the degree of stenosis was evaluated.
RESULTS
The mean levels of hs-CRP in the stable angina group, unstable angina group and the group with normal coronary angiography were 2.46 ± 1.79, 4.84 ± 3.38, and 2.95 ± 2.57 mg/L, respectively. The results show that the mean levels of hs-CRP in patients with unstable angina was significantly higher compared to patients with stable angina (P < 0.050) and patients with normal coronary angiography (P < 0.001). However, a statistical difference between the mean CRP levels in patients with stable angina and patients with normal angiography results was not seen (P > 0.050). A significant relationship between arterial stenosis points and hs-CRP levels in patients with stable angina was not seen (P = 0.985).
CONCLUSION
The findings suggest that it seems hs-CRP level in patients with unstable angina were significantly higher than those in patients with stable angina and patients with normal coronary angiography. It also appears that the level of hs-CRP in patients with unstable angina is associated with the severity of coronary stenosis. Given the finding of consistent results, the use of hs-CRP as a prognostic factor in these patients may be useful.
背景
高敏C反应蛋白（hs-CRP）炎症生物标志物是已被研究的冠状动脉疾病（CAD）预后的最佳信息性标志物之一。一些研究发现hs-CRP与CAD有直接关联。本研究的目的是确定稳定型和不稳定型心绞痛患者血清hs-CRP水平与冠状动脉狭窄严重程度之间的关系。
方法
在一项横断面研究中，2012年于伊朗阿瓦士戈勒斯坦医院接受冠状动脉造影的150例患者被分为三组：稳定型心绞痛组（n = 50）、不稳定型心绞痛组（n = 50）和冠状动脉造影正常组（n = 50）。通过酶联免疫吸附测定法在血管造影术前测量患者的hs-CRP水平，比较三组之间的水平，并评估其与狭窄程度的相关性。
结果
稳定型心绞痛组、不稳定型心绞痛组和冠状动脉造影正常组的hs-CRP平均水平分别为2.46±1.79、4.84±3.38和2.95±2.57mg/L。结果显示，不稳定型心绞痛患者的hs-CRP平均水平显著高于稳定型心绞痛患者（P < 0.050）和冠状动脉造影正常的患者（P < 0.001）。然而，稳定型心绞痛患者与冠状动脉造影结果正常的患者之间的平均CRP水平未见统计学差异（P > 0.050）。稳定型心绞痛患者的动脉狭窄积分与hs-CRP水平之间未见显著关系（P = 0.985）。
结论
研究结果表明，不稳定型心绞痛患者的hs-CRP水平似乎显著高于稳定型心绞痛患者和冠状动脉造影正常的患者。不稳定型心绞痛患者的hs-CRP水平似乎也与冠状动脉狭窄的严重程度相关。鉴于结果一致，将hs-CRP用作这些患者的预后因素可能是有用的。
Zotero 插件