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共轭亚油酸:有益还是有害的营养素。

Conjugated Linoleic Acid: good or bad nutrient.

机构信息

Department of Physiology, Universidade Federal de São Paulo (UNIFESP), São Paulo/SP, Brazil.

出版信息

Diabetol Metab Syndr. 2010 Oct 30;2:62. doi: 10.1186/1758-5996-2-62.

DOI:10.1186/1758-5996-2-62
PMID:21034495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2990727/
Abstract

Conjugated linoleic acid (CLA) is a class of 28 positional and geometric isomers of linoleic acid octadecadienoic.Currently, it has been described many benefits related to the supplementation of CLA in animals and humans, as in the treatment of cancer, oxidative stress, in atherosclerosis, in bone formation and composition in obesity, in diabetes and the immune system. However, our results show that, CLA appears to be not a good supplement in patients with cachexia.

摘要

共轭亚油酸(CLA)是亚油酸十八碳二烯酸的一组 28 个位置和立体异构体。目前,已经描述了 CLA 补充在动物和人类中的许多益处,如治疗癌症、氧化应激、动脉粥样硬化、肥胖症中的骨形成和组成、糖尿病和免疫系统。然而,我们的结果表明,CLA 似乎不是恶病质患者的好补充剂。

相似文献

1
Conjugated Linoleic Acid: good or bad nutrient.共轭亚油酸:有益还是有害的营养素。
Diabetol Metab Syndr. 2010 Oct 30;2:62. doi: 10.1186/1758-5996-2-62.
2
Biological effects of conjugated linoleic acids in health and disease.共轭亚油酸在健康与疾病中的生物学效应
J Nutr Biochem. 2006 Dec;17(12):789-810. doi: 10.1016/j.jnutbio.2006.02.009. Epub 2006 May 2.
3
Methods for analysis of conjugated linoleic acids and trans-18:1 isomers in dairy fats by using a combination of gas chromatography, silver-ion thin-layer chromatography/gas chromatography, and silver-ion liquid chromatography.运用气相色谱法、银离子薄层色谱/气相色谱法以及银离子液相色谱法联用分析乳脂肪中共轭亚油酸和反式-18:1异构体的方法。
J AOAC Int. 2004 Mar-Apr;87(2):545-62.
4
Conjugated linoleic acid: a review.共轭亚油酸综述。
Altern Med Rev. 2001 Aug;6(4):367-82.
5
The effects of conjugated linoleic acid on human health-related outcomes.共轭亚油酸对人体健康相关结果的影响。
Proc Nutr Soc. 2005 May;64(2):171-82. doi: 10.1079/pns2005418.
6
Health benefits of conjugated linoleic acid (CLA).共轭亚油酸(CLA)对健康的益处。
Obes Res Clin Pract. 2014 Nov-Dec;8(6):e525-32. doi: 10.1016/j.orcp.2013.10.001. Epub 2013 Nov 5.
7
Conjugated linoleic acid and cardiac health: oxidative stress and energetic metabolism in standard and sucrose-rich diets.共轭亚油酸与心脏健康:标准饮食和高蔗糖饮食中的氧化应激与能量代谢
Eur J Pharmacol. 2008 Jan 28;579(1-3):318-25. doi: 10.1016/j.ejphar.2007.11.008. Epub 2007 Nov 13.
8
Systematic evaluation on the effectiveness of conjugated linoleic acid in human health.共轭亚油酸在人类健康方面的有效性的系统评价。
Crit Rev Food Sci Nutr. 2017 Jan 2;57(1):1-7. doi: 10.1080/10408398.2012.716800.
9
Improved identification of conjugated linoleic acid isomers using silver-ion HPLC separations.使用银离子高效液相色谱分离法改进共轭亚油酸异构体的鉴定。
J AOAC Int. 2004 Mar-Apr;87(2):563-8.
10
Antimutagenic and some other effects of conjugated linoleic acid.共轭亚油酸的抗诱变及其他一些作用。
Br J Nutr. 2000 May;83(5):459-65.

引用本文的文献

1
Conjugated Linoleic Acid and Its Beneficial Effects in Obesity, Cardiovascular Disease, and Cancer.共轭亚油酸及其在肥胖症、心血管疾病和癌症中的有益作用。
Nutrients. 2020 Jun 28;12(7):1913. doi: 10.3390/nu12071913.
2
Serum levels of appetite-regulating hormones and pro-inflammatory cytokines are ameliorated by a CLA diet and endurance exercise in rats fed a high-fat diet.在喂食高脂饮食的大鼠中,共轭亚油酸(CLA)饮食和耐力运动可改善食欲调节激素和促炎细胞因子的血清水平。
J Exerc Nutrition Biochem. 2015 Dec 31;19(4):303-9. doi: 10.5717/jenb.2015.15120905.
3
Conjugated linoleic acid supplementation enhances insulin sensitivity and peroxisome proliferator-activated receptor gamma and glucose transporter type 4 protein expression in the skeletal muscles of rats during endurance exercise.共轭亚油酸补充剂可增强耐力运动期间大鼠骨骼肌中的胰岛素敏感性、过氧化物酶体增殖物激活受体γ以及葡萄糖转运蛋白4的蛋白表达。
Iran J Basic Med Sci. 2016 Jan;19(1):20-7.
4
CLA reduces inflammatory mediators from A427 human lung cancer cells and A427 conditioned medium promotes differentiation of C2C12 murine muscle cells.共轭亚油酸可减少A427人肺癌细胞中的炎症介质,且A427条件培养基可促进C2C12小鼠肌肉细胞的分化。
Lipids. 2013 Jan;48(1):29-38. doi: 10.1007/s11745-012-3734-6. Epub 2012 Nov 7.

本文引用的文献

1
Conjugated linoleic acid isomers: differences in metabolism and biological effects.共轭亚油酸异构体:代谢与生物学效应的差异
Biofactors. 2009 Jan-Feb;35(1):105-11. doi: 10.1002/biof.13.
2
Phytochemicals and regulation of the adipocyte life cycle.植物化学物质与脂肪细胞生命周期的调控
J Nutr Biochem. 2008 Nov;19(11):717-26. doi: 10.1016/j.jnutbio.2007.12.007. Epub 2008 May 20.
3
Conjugated linoleic acid (CLA) and obesity.共轭亚油酸(CLA)与肥胖
Public Health Nutr. 2007 Oct;10(10A):1181-6. doi: 10.1017/S1368980007000687.
4
Conjugated linoleic acid preserves gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma.共轭亚油酸可维持荷结肠-26腺癌小鼠腓肠肌的肌肉质量。
Res Nurs Health. 2005 Feb;28(1):48-55. doi: 10.1002/nur.20052.
5
Dietary conjugated linoleic acid decreased cachexia, macrophage tumor necrosis factor-alpha production, and modifies splenocyte cytokines production.膳食共轭亚油酸可减轻恶病质、降低巨噬细胞肿瘤坏死因子-α的产生,并改变脾细胞细胞因子的产生。
Exp Biol Med (Maywood). 2003 Jan;228(1):51-8. doi: 10.1177/153537020322800107.
6
Conjugated linoleic acid metabolism.共轭亚油酸代谢。
Curr Opin Lipidol. 2002 Jun;13(3):261-6. doi: 10.1097/00041433-200206000-00005.