Department of Biology, 501 ASI Bldg, Penn State University, University Park, PA 16802, USA.
Vaccine. 2010 Dec 10;29(1):11-6. doi: 10.1016/j.vaccine.2010.10.029. Epub 2010 Oct 27.
Whooping cough, caused by B. pertussis and B. parapertussis, has increased in incidence throughout much of the developed world since the 1980s despite high vaccine coverage, causing an increased risk of infection in infants who have substantial disease-induced mortality. Duration of immunity and epidemically significant routes of transmission across age groups remain unclear and deserve further investigation to inform vaccination strategies to better control pertussis burden. The authors analyze age- and species-specific whooping cough tests and vaccine histories in Massachusetts from 1990 to 2008. On average, the disease-free duration is 10.5 years. However, it has been decreasing over time, possibly due to a rising force of infection through increased circulation. Despite the importance of teenage cases during epidemics, wavelet analyses suggest that they are not the most important source of transmission to infants. In addition, the data indicate that the B. pertussis vaccine is not protective against disease induced by B. parapertussis.
百日咳由 B. pertussis 和 B. parapertussis 引起，尽管疫苗接种率很高，但自 20 世纪 80 年代以来，在许多发达国家的发病率都有所上升，这导致了婴儿感染的风险增加，而婴儿因该病的死亡率很高。免疫持续时间和在各年龄组中具有流行病学意义的传播途径仍不清楚，值得进一步研究，以制定更好的疫苗接种策略来控制百日咳负担。作者分析了马萨诸塞州 1990 年至 2008 年期间的年龄和物种特异性百日咳检测和疫苗接种史。平均而言，无病持续时间为 10.5 年。然而，它随着时间的推移而减少，可能是由于感染率上升导致循环增加。尽管青少年病例在流行期间很重要，但小波分析表明，他们并不是向婴儿传播的最重要来源。此外，数据表明，百日咳疫苗不能预防由 B. parapertussis 引起的疾病。
