Department of Applied Chemistry, Faculty of Chemistry, University of The Basque Country, Manuel de Lardizabal, 3, 20018, San Sebastian, Spain.
Trends Microbiol. 2010 Dec;18(12):569-76. doi: 10.1016/j.tim.2010.09.007. Epub 2010 Oct 28.
Asexual development in Aspergillus nidulans begins in superficial hyphae as the programmed emergence of successive pseudohyphal modules, collectively known as the conidiophore, and is completed by a layer of specialized cells (phialides) giving rise to chains of aerial spores. A discrete number of regulatory factors present in hyphae play different stage-specific roles in pseudohyphal modules, depending on their cellular localization and protein-protein interactions. Their multiple roles include the timely activation of a sporulation-specific pathway that governs phialide and spore formation. Such functional versatility provides for a new outlook on morphogenetic change and the ways we should study it.
在构巢曲霉中，无性发育始于浅层菌丝，表现为连续的拟菌丝模块的程序性出现，这些模块统称为分生孢子梗，最后由一层专门的细胞（产孢细胞）完成，产生气生孢子链。菌丝中存在的一系列离散调控因子，根据其细胞定位和蛋白-蛋白相互作用，在拟菌丝模块中发挥不同的特定阶段作用。它们的多种作用包括及时激活专用于孢子形成的途径，该途径控制产孢细胞和孢子的形成。这种多功能性为形态发生变化及其研究方法提供了新的视角。
