Harris Steven D
Department of Plant Pathology, University of Nebraska, Lincoln, NE 68688-0660, USA.
Mol Microbiol. 2009 Sep;73(5):733-6. doi: 10.1111/j.1365-2958.2009.06803.x. Epub 2009 Jul 21.
In Aspergillus nidulans, asexual development culminates in the formation of a multicellular conidiophore that bears spores known as conidia. Although several factors required for conidiophore formation have been characterized, the mechanisms underlying the transition from vegetative growth to development remain obscure. However, the recent characterization of two of these factors, FlbB and FlbE, provides important new insight. Notably, these studies suggest that the Spitzenkörper (i.e. apical body), which is known to regulate hyphal morphogenesis, might also serve as a signalling hub that co-ordinates development transitions.
在构巢曲霉中，无性发育最终形成一个带有称为分生孢子的孢子的多细胞分生孢子梗。尽管已经鉴定出分生孢子梗形成所需的几个因素，但从营养生长向发育转变的潜在机制仍然不清楚。然而，最近对其中两个因素FlbB和FlbE的鉴定提供了重要的新见解。值得注意的是，这些研究表明，已知调节菌丝形态发生的顶体，也可能作为协调发育转变的信号枢纽。
