Jackson Edan, Li Josh, Weerasinghe Thilini, Li Xin
Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Department of Botany, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Pathogens. 2024 Sep 24;13(10):823. doi: 10.3390/pathogens13100823.
is one of the most economically important plant fungal pathogens, causing devastating Fusarium wilt diseases on a diverse range of hosts, including many key crop plants. Consequently, has been the subject of extensive research to help develop and improve crop protection strategies. The sequencing of the genome 14 years ago has greatly accelerated the discovery and characterization of key genes contributing to biology and virulence. In this review, we summarize important findings on the molecular mechanisms of growth, reproduction, and virulence. In particular, we focus on genes studied through mutant analysis, covering genes involved in diverse processes such as metabolism, stress tolerance, sporulation, and pathogenicity, as well as the signaling pathways that regulate them. In doing so, we hope to present a comprehensive review of the molecular understanding of that will aid the future study of this and related species.
是最重要的经济植物真菌病原体之一，在包括许多重要农作物在内的多种寄主上引发毁灭性的镰刀菌枯萎病。因此，它一直是广泛研究的对象，以帮助制定和改进作物保护策略。14年前该真菌基因组的测序极大地加速了对有助于其生物学特性和毒力的关键基因的发现和表征。在这篇综述中，我们总结了关于其生长、繁殖和毒力分子机制的重要发现。特别是，我们专注于通过突变分析研究的基因，涵盖参与代谢、胁迫耐受性、孢子形成和致病性等不同过程的基因，以及调节这些过程的信号通路。通过这样做，我们希望对该真菌的分子理解进行全面综述，这将有助于对该物种及相关物种的未来研究。
