Singapore National Eye Centre and Singapore Eye Research Institute, Singapore, Republic of Singapore.
Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research), Singapore, Republic of Singapore.
Ophthalmology. 2014 Aug;121(8):1566-71. doi: 10.1016/j.ophtha.2014.02.006. Epub 2014 Mar 25.
To evaluate the occurrence of myopia in Asian subjects with angle closure and to assess the ocular biometric parameters in these subjects.
Cross-sectional study.
We prospectively recruited 427 angle-closure subjects (143 primary angle-closure suspects, 75 patients with primary angle closure, 165 patients with primary angle-closure glaucoma, and 44 patients with acute primary angle closure) from a Singapore hospital.
Refractive status was derived from the spherical equivalent of autorefraction. A-scan biometry (Nidek Echoscan Ultrasound US-800; Nidek Co., Tokyo, Japan) was performed to obtain anterior chamber depth (ACD), axial length (AL), lens thickness, and vitreous cavity length (VL). Anterior segment optical coherence tomography was performed to measure lens vault.
Refractive status was categorized as myopia (≤-0.50 diopter [D]), emmetropia (-0.50 to +0.50 D), and hyperopia (≥+0.50 D).
The mean age ± standard deviation of study subjects was 65.6 ± 7.6 years, with most being Chinese (n = 394; 92.3%) and women (n = 275; 64.4%). Overall, myopia was present in 94 subjects (22%), hyperopia was present in 222 subjects (52%), and emmetropia was present in 111 subjects (26%). Of the 94 myopic angle-closure patients, 28 (29.8%) were categorized as having moderate myopia (≤-2.0 to -5.0 D) and 11 (11.7%) were categorized as having high myopia (≤-5.00 D). Although myopic angle-closure subjects had longer ALs (P<0.001) and VLs (P = 0.001) than their emmetropic and hyperopic counterparts, there were no significant differences in ACD (P = 0.77), lens thickness (P = 0.44), or lens vault (P = 0.053).
Almost one quarter of angle-closure patients were myopic. Myopic angle-closure subjects had longer VLs and ALs, but there was no difference in ACD. With the increasing rate of myopia in many East Asian populations, there may be many subjects with axial myopia but shallow ACD and angle closure. The implication is that ophthalmologists should not assume that glaucoma patients who are myopic have open angles.
评估亚洲闭角型青光眼患者的近视发生率，并评估这些患者的眼部生物测量参数。
横断面研究。
我们前瞻性地招募了来自新加坡一家医院的 427 名闭角型青光眼患者（143 名原发性闭角型青光眼可疑患者、75 名原发性闭角型青光眼患者、165 名原发性闭角型青光眼患者和 44 名急性原发性闭角型青光眼患者）。
通过自动折射的等效球镜度数得出屈光状态。使用 A 扫描生物测量仪（日本尼德克公司的 Echoscan Ultrasound US-800）获得前房深度（ACD）、眼轴长度（AL）、晶状体厚度和玻璃体腔长度（VL）。使用眼前节光学相干断层扫描仪测量晶状体拱高。
屈光状态分为近视（≤-0.50 屈光度[D]）、正视（-0.50 至+0.50 D）和远视（≥+0.50 D）。
研究对象的平均年龄±标准差为 65.6±7.6 岁，多数为中国人（n=394；92.3%）和女性（n=275；64.4%）。总体而言，94 名患者（22%）为近视，222 名患者（52%）为远视，111 名患者（26%）为正视。在 94 名近视性闭角型青光眼患者中，28 名（29.8%）为中度近视（≤-2.0 至-5.0 D），11 名（11.7%）为高度近视（≤-5.00 D）。尽管近视性闭角型青光眼患者的 AL 和 VL 较长（P<0.001），但与正视和远视患者相比，ACD 无显著差异（P=0.77），晶状体厚度（P=0.44）和晶状体拱高（P=0.053）也无显著差异。
近四分之一的闭角型青光眼患者为近视。近视性闭角型青光眼患者的 VL 和 AL 较长，但 ACD 无差异。随着东亚许多人群近视率的增加，可能会有许多轴向近视但 ACD 较浅和闭角型的患者。这意味着眼科医生不应假设近视的青光眼患者具有开放的角度。
