对具有抗真菌活性的 Duriaei 亚属 Eryngium juresianum (M. Laínz) M. Laínz 的挥发性提取物的组成进行了分析。
Composition of a volatile extract of Eryngium duriaei subsp. juresianum (M. Laínz) M. Laínz, signalised by the antifungal activity.
机构信息
Centro de Estudos Farmacêuticos/Faculdade de Farmácia, Universidade de Coimbra, 3000-548 Coimbra, Portugal.
出版信息
J Pharm Biomed Anal. 2011 Feb 20;54(3):619-22. doi: 10.1016/j.jpba.2010.09.039. Epub 2010 Oct 8.
The composition of a volatile extract of Eryngium duriaei subsp. juresianum, signalised by the antifungal activity (MIC values=0.16-0.32 μL mL(-1)) against several dermatophyte species (Trichophyton mentagrophytes, T. rubrum, Epidermophyton floccosum; T. verrucosum, T. mentagrophytes var interdigitale, Microsporum canis and M. gypseum) was established following a combined methodology of GC, GC-MS and an exclusive (13)C NMR technique that does not require prior isolation of compounds. Twenty-five components were identified accounting 84.6% of the whole composition. Major compound was found to be α-neocallitropsene (26.0%) although the dominance of caryophyllane derived compounds, the most probable responsible for the antifungal activity, namely isocaryophyllen-14-al (16.2%), 14-hidroxy-β-caryophyllene (13.4%), caryophyllene oxide (7.6%) and E-β-caryophyllene (6.3%).
龙舌兰 Duriaei 亚种 juresianum 的挥发性提取物的成分，表现出抗真菌活性（MIC 值=0.16-0.32 μL mL(-1))，针对几种皮肤真菌（毛癣菌属 mentagrophytes、T. rubrum、絮状表皮癣菌；T. verrucosum、T. mentagrophytes var interdigitale、犬小孢子菌和石膏小孢子菌），采用 GC、GC-MS 和一种独特的（13)C NMR 技术建立，该技术不需要化合物的预先分离。鉴定出 25 种成分，占总成分的 84.6%。发现主要化合物为α-neocallitropsene（26.0%），尽管源自石竹烷的化合物占主导地位，最有可能是抗真菌活性的原因，即异石竹烯-14-醛（16.2%）、14-羟基-β-石竹烯（13.4%）、石竹烯氧化物（7.6%）和 E-β-石竹烯（6.3%）。
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