Department of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara, Nara, Japan.
Anticancer Res. 2010 Oct;30(10):4097-101.
Expression of ligands of natural killer group 2D (NKG2D) immunoreceptors, such as major histocompatibility complex class I-related chain A/B (MICA/B), has been proposed to play an important role in tumour immunosurveillance. Soluble forms of MICA/B are increased in sera of cancer patients and are postulated to impair antitumour immune response by downregulating expression of NKG2D immunoreceptors. Serum levels of soluble MICA have been shown to be of diagnostic significance in malignant diseases.
The potential of soluble MICB (sMICB) as a marker for oral squamous cell carcinoma (OSCC) was investigated.
sMICB levels did not differ significantly from those in normal control individuals. However, the findings indicate that sMICB levels are significantly increased in stage IV OSCC and high sMICB levels are significantly associated with decreased survival rates in patients.
自然杀伤细胞组 2D（NKG2D）免疫受体配体的表达，如主要组织相容性复合体 I 类相关链 A/B（MICA/B），被认为在肿瘤免疫监视中发挥重要作用。癌症患者血清中可溶性 MICA/B 增加，据推测通过下调 NKG2D 免疫受体的表达来损害抗肿瘤免疫反应。可溶性 MICA 的血清水平在恶性疾病中具有诊断意义。
研究可溶性 MICB（sMICB）作为口腔鳞状细胞癌（OSCC）标志物的潜力。
sMICB 水平与正常对照组无显著差异。然而，研究结果表明，sMICB 水平在 IV 期 OSCC 中显著升高，高水平 sMICB 与患者生存率降低显著相关。
