Fernández-Morera Juan Luís, Rodríguez-Rodero Sandra, Lahoz Carlos, Tuñon Alberto, Astudillo Aurora, Garcia-Suarez Olivia, Martínez-Borra Jesús, López-Vázquez Antonio, Rodrigo Luis, Gonzalez Segundo, López-Larrea Carlos
Unidad de Histocompatibilidad y Transplantes, Hospital Universitario Central de Asturias, Oviedo, Spain.
Hum Immunol. 2008 Apr-May;69(4-5):235-40. doi: 10.1016/j.humimm.2008.01.021. Epub 2008 Apr 7.
Recent studies demonstrated that dysregulation of NKG2D and its ligands, leading to activation of autoreactive effector cells, can trigger autoimmune diseases, but soluble forms of these ligands can downmodulate NKG2D expression in T effector cells. We investigated the presence of soluble major histocompatibility complex class I chain-related A or B (MICA or MICB) molecules in sera of multiple sclerosis (MS) patients and whether they play a role in the progression of the disease. Although soluble MICA serum levels did not differ, soluble MICB serum levels were higher in MS patients compared with controls. Moreover, the highest MICB levels were in MS patients during relapses. Using immunohistochemistry techniques, it was possible to locate MIC expression in neurons of MS demyelinating plaques that were intracellularly accumulated. Elevated soluble MICB levels exist in serum of multiple sclerosis patients related with disease activity. This may contribute to the modulation of immune response activity during relapses.
最近的研究表明，NKG2D及其配体的失调会导致自身反应性效应细胞的激活，进而引发自身免疫性疾病，但这些配体的可溶性形式可下调T效应细胞中NKG2D的表达。我们研究了多发性硬化症（MS）患者血清中可溶性主要组织相容性复合体I类链相关分子A或B（MICA或MICB）的存在情况，以及它们是否在疾病进展中发挥作用。虽然可溶性MICA血清水平没有差异，但与对照组相比，MS患者的可溶性MICB血清水平更高。此外，复发期MS患者的MICB水平最高。使用免疫组织化学技术，能够在细胞内积聚的MS脱髓鞘斑块的神经元中定位MIC的表达。多发性硬化症患者血清中存在与疾病活动相关的可溶性MICB水平升高的情况。这可能有助于在复发期间调节免疫反应活性。
