Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
Am J Trop Med Hyg. 2010 Nov;83(5):973-80. doi: 10.4269/ajtmh.2010.09-0445.
Microscopic examination of placental tissue can provide an accurate assessment of malaria infection during pregnancy. In this cross-sectional study of 193 women in Iquitos, Peru, 1.0% and 6.6% had parasites in the peripheral blood as detected by microscopy and polymerase chain reaction, respectively. However, 22% had placental malaria pigment indicating past, subclinical infections. Placental tissues with pigment from 24 cases were matched by gravidity and month of delivery to 24 controls and histopathologically examined. Cases had significantly higher number of monocytes in the intervillous space (44.7 versus 25.5; P = 0.012). Pigmented monocytes in fetal vessels were present in 33.3% of cases. This study demonstrated that subclinical malarial infection occurred frequently in pregnant women and is associated with increased presence of monocytes in the placenta. Pigmented monocytes in fetal vessels suggest parasites can breach the placental barrier and enter the fetal circulation.
对胎盘组织进行显微镜检查可以准确评估孕妇在怀孕期间是否受到疟疾感染。在秘鲁伊基托斯进行的这项横断面研究中，193 名妇女中分别有 1.0%和 6.6%通过显微镜和聚合酶链反应检测到外周血中有寄生虫，但有 22%的人有胎盘疟色素，表明过去存在亚临床感染。将 24 例有色素的胎盘组织与 24 例对照按孕次和分娩月份进行匹配，并进行组织病理学检查。病例组绒毛间隙中的单核细胞数量明显更高（44.7 比 25.5；P = 0.012）。在 33.3%的病例中，胎儿血管中的色素性单核细胞存在。这项研究表明，亚临床疟原虫感染在孕妇中很常见，并且与胎盘内单核细胞的存在增加有关。胎儿血管中的色素性单核细胞提示寄生虫可以突破胎盘屏障并进入胎儿循环。
