Service de Gynécologie Obstétrique, Centre Hospitalier de l'Ouest Guyanais, Saint Laurent du Maroni, Guyane Française.
Am J Trop Med Hyg. 2010 Nov;83(5):1100-5. doi: 10.4269/ajtmh.2010.10-0370.
The clays consumed by geophagous individuals contain large quantities of aluminum, a known neurological and hematological toxin. This is the first study to evaluate the risk of aluminum poisoning in geophagous individuals. Blind determinations of plasma and urinary aluminum concentrations were carried out in 98 anemic geophagous pregnant women and 85 non-anemic non-geophagous pregnant women. Aluminum concentrations were significantly higher (P < 0.0001) in the geophagous anemic women than in the controls, with odds ratios of 6.83 (95% confidence interval [CI] = 2.72-19.31) for plasma concentrations (13.92 ± 14.09 μg/L versus 4.95 ± 7.11 μg/L) and 5.44 (95% CI = 2.17-14.8) for urinary concentrations (92.83 ± 251.21 μg/L versus 12.11 ± 23 μg/L). The ingested clay is the most likely source of this overexposure to aluminum. If confirmed, the clinical consequences of this absorption for pregnant women and their offspring should be explored.
食土人群所消耗的黏土中含有大量的铝，而铝是一种已知的神经和血液毒素。这是第一项评估食土人群铝中毒风险的研究。本研究对 98 名贫血的食土孕妇和 85 名非贫血非食土孕妇进行了血浆和尿液铝浓度的盲法检测。食土贫血孕妇的血浆和尿液铝浓度明显高于对照组（P<0.0001），血浆浓度的比值比（OR）为 6.83（95%可信区间[CI]为 2.72-19.31）（13.92±14.09μg/L 比 4.95±7.11μg/L），尿液浓度的 OR 为 5.44（95%CI=2.17-14.8）（92.83±251.21μg/L 比 12.11±23μg/L）。这种过度暴露于铝的最可能来源是摄入的黏土。如果得到证实，应该探讨这种吸收对孕妇及其后代的临床后果。
