Department of Plant Breeding and Genetics, Max Planck Institute for Plant Breeding Research, Cologne, Germany.
Nat Genet. 2010 Dec;42(12):1135-9. doi: 10.1038/ng.704. Epub 2010 Oct 31.
Accumulation of genetic incompatibilities within species can lead to reproductive isolation and, potentially, speciation. In this study, we show that allelic variation at SRF3 (Strubbelig Receptor Family 3), encoding a receptor-like kinase, conditions the occurrence of incompatibility between Arabidopsis thaliana accessions. The geographical distribution of SRF3 alleles reveals that allelic forms causing epistatic incompatibility with a Landsberg erecta allele at the RPP1 resistance locus are present in A. thaliana accessions in central Asia. Incompatible SRF3 alleles condition for an enhanced early immune response to pathogens as compared to the resistance-dampening effect of compatible SRF3 forms in isogenic backgrounds. Variation in disease susceptibility suggests a basis for the molecular patterns of a recent selective sweep detected at the SRF3 locus in central Asian populations.
遗传不相容性在物种内的积累可能导致生殖隔离，并可能导致物种形成。在这项研究中，我们表明，编码受体样激酶的 SRF3（Strubbelig 受体家族 3）等位基因的变异条件是拟南芥品系之间不相容性的发生。SRF3 等位基因的地理分布表明，与 RPP1 抗性基因座中的 Landsberg erecta 等位基因产生上位性不相容的等位基因形式存在于中亚的拟南芥品系中。与在同基因背景下具有降低抗性作用的相容 SRF3 形式相比，不相容的 SRF3 等位基因条件下可增强对病原体的早期免疫反应。对疾病易感性的变异表明，在中亚人群中最近在 SRF3 基因座上检测到的选择清除的分子模式的基础。
